ArticleActa ophthalmologica2025
'EarlyAMDRate': A grading instrument for OCT-based assessment of early lesions caused by age-related macular degeneration.
Article in Acta ophthalmologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Review of emerging imaging findings to reveal a broader spectrum of lesions in AMD.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- A Simulation Procedure for Stereological Correction of Early AMD Lesion Sizes Observed in Single OCT-B-Scans.Translational vision science & technology · 2026Article
- 'EarlyAMDRate': A grading instrument for OCT-based assessment of early lesions caused by age-related macular degeneration.Acta ophthalmologica · 2025Article
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4 authors.
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Abstract
BACKGROUND AND
objectivesLong before any signs of age-related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation of deposits of extracellular debris and formation of lesions within the outermost layers of the retina. For a reliable imaging of lesions in these early stages, optical coherence tomography (OCT) turned out to be largely preferable to colour fundus photography. However, an adequate grading instrument for Early-AMD lesions within OCT data is missing in the literature as yet. The present paper aims to fill this gap.
methods'EarlyAMDRate', an instrument for OCT-based grading of Early-AMD lesions, is presented and documented. It comprises a questionnaire assessing a given lesion with respect to its relative position and interaction with the surrounding retinal layers, its brightness, special properties and state of progression (if applicable). Furthermore, the grading procedure includes a graphical masking of the lesion within the OCT image.
resultsFor a consecutive sample of N = 100 Early-AMD patients, the 'EarlyAMDRate' grading instrument has been applied to leading OCT scans. Examples of masked lesions and processed grading questionnaires are provided. Both raw lesion diameters and cutting sizes follow a log-normal sample distribution.
conclusions'EarlyAMDRate' allows for unprecedented detail of description for single Early-AMD lesions which is adequate to the precision of underlying OCT imaging. The obtained grading information allows for a tracking of single lesions and their properties over time as well as for the generation of well-differentiated metric phenotypes for description of Early-AMD.
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