Evidence map›Paper›PMID 40159278›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025

European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC and endorsed by the Asia Pacific Heart Rhythm Society, the Canadian Heart Rhythm Society, the Heart Rhythm Society, and the Latin American Heart Rhythm Society.

Michael Glikson, Haran Burri, Amr Abdin, Oscar Cano, Karol Curila, Jan De Pooter, Juan C Diaz, Inga Drossart, Weijian Huang, Carsten W Israel and 23 more

Registry-linked trialAbstract readConsensus Statement
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664189 (Left Bundle Branch Pacing + Coronary Sinus Pacing Versus Left Bundle Branch Pacing Alone for Cardiac Resynchronization Therapy in Patients Eligible for CRT-P A Randomized Crossover Pilot Clinical Trial), which is not on this map. Cited by 90 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07664189 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Left Bundle Branch Pacing + Coronary Sinus Pacing Versus Left Bundle Branch Pacing Alone for Cardiac Resynchronization Therapy in Patients Eligible for CRT-P A Randomized Crossover Pilot Clinical Trial

TypeinterventionalSponsorClinica Cardio VIDRan2026 to 2027Enrolled10ConditionsHeart Failure Low OutputArmsLeft Bundle Branch Optimized CRT, Stimulation of the left bundle branch area (LBBAP)
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Conduction system vs. biventricular pacing in heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  2. Conduction system pacing vs. biventricular pacing for cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis considering randomized controlled trials and observational studies.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  3. Conduction system pacing for cardiac resynchronization therapy: a systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Procedural performance and safety of a helix locking tool for left bundle branch pacing: a prospective multicenter study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  10. Electrophysiological and histological comparisons of left bundle branch pacing vs. left ventricular septal pacing in canine self-controlled models.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Decoding the evidence emerging from the studies comparing conduction system pacing with conventional cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  16. Article
  17. Conduction system pacing: what emerging evidence and what indications?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Review
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Michael GliksonJesselson Integrated Heart Center, Shaare Zedek Medical Center, 12 Shmuel Beit Street, 9103102, Jerusalem, Israel.ORCID 0000-0001-5706-0395
Haran BurriCardiac Pacing Unit, Cardiology Department, University Hospital of Geneva, Geneva, Switzerland.ORCID 0000-0002-4393-5338
Amr AbdinInternal Medicine Clinic III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Homburg/Saar, Germany.ORCID 0000-0003-0847-1694
Oscar CanoUnidad de Arritmias, Hospital Universitari i Politècnic La Fe, Valencia, Spain.ORCID 0000-0001-6783-0138
Karol CurilaCardiocenter, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.ORCID 0000-0003-3523-6358
Jan De PooterDepartment of Cardiology, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0002-3135-8676
Juan C DiazClínica Las Vegas, Universidad CES, Medellín, Colombia.ORCID 0000-0003-0887-1700
Inga DrossartESC Patient Forum, Sophia Antipolis, France.ORCID 0000-0002-6440-1642
Weijian HuangDepartment of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0003-2958-134X
Carsten W IsraelDepartment of Medicine-Cardiology, Diabetology and Nephrology, Bethel-Clinic, Bielefeld, Germany.ORCID 0000-0003-1101-7556
Marek JastrzębskiFirst Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Medical College, Krakow, Poland.ORCID 0000-0002-3318-6601
Jacqueline JozaDepartment of Medicine, McGill University Health Centre, Montreal, Canada.ORCID 0000-0003-0956-688X
Jarkko KarvonenHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-0686-2782
Daniel KeeneNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-7472-7358
Christophe LeclercqService de Cardiologie et Maladies Vasculaires, Université de Rennes, CHU Rennes, INSERM, LTSI-UMR 1099, F-35000 Rennes, France.ORCID 0000-0002-4399-5568
Wilfried MullensHasselt University, Ziekenhuis Oost-Limburg, Genk, Belgium.ORCID 0000-0001-9995-8590
Margarida Pujol-LopezInstitut Clínic Cardiovascular (ICCV), Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.ORCID 0000-0002-4523-6469
Archana RaoLiverpool Heart and Chest Hospital, Liverpool, UK.ORCID 0000-0002-3893-3944
Kevin VernooyDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.ORCID 0000-0002-8818-5964
Pugazhendhi VijayaramanGeisinger Commonwealth School of Medicine, Geisinger Heart Institute, Wilkes-Barre, PA, USA.ORCID 0000-0003-2230-100X
Francesco ZanonSanta Maria della Misericordia Hospital, Rovigo, Italy.ORCID 0000-0003-2673-3918
Yoav MichowitzJesselson Integrated Heart Center, Shaare Zedek Medical Center, 12 Shmuel Beit Street, 9103102, Jerusalem, Israel.ORCID 0000-0002-5665-3735
Jens Cosedis NielsenDepartment of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Lucas BoersmaCardiology Department, St. Antonius Hospital, Nieuwegein, The  Netherlands.
Carina Blomström-LundqvistDepartment of Cardiology, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Mads Brix KronborgDepartment of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mina K ChungCardiac Pacing & Electrophysiology, Department of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute, Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case western Reserve University, Cleveland, OH, USA.
Hung Fat TseCardiology Division, Department of Medicine, Queen Mary Hospital, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.
Habib Rehman KhanWestern University, London Ontario, Canada.
Francisco LeyvaAston Medical School, Aston University, Aston Triangle, Birmingham, UK.
Ulises Rojel-MartinezArrhythmias ad Pacing Service, Cardiology Division, Department of Medicine, South Medical Center, Puebla, Mexico.
Marcin RucińskiESC Patient Forum, Sophia Antipolis, France.
Niraj VarmaCardiac Pacing & Electrophysiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conduction system pacing (CSP) is being increasingly adopted as a more physiological alternative to right ventricular and biventricular pacing. Since the 2021 European Society of Cardiology pacing guidelines, there has been growing evidence that this therapy is safe and effective. Furthermore, left bundle branch area pacing was not covered in these guidelines due to limited evidence at that time. This Clinical Consensus Statement provides advice on indications for CSP, taking into account the significant evolution in this domain.

Indexed as

Arrhythmias, CardiacCardiac Pacing, ArtificialCardiologyHeart Conduction SystemAction PotentialsEuropeHeart RateHumansSocieties, MedicalTreatment OutcomeBiventricular pacingCardiac resynchronization therapyConduction system pacingHis bundle pacingIndicationsLeft bundle branch area pacing

Identifiers

PMID40159278
PMCPMC11957271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.