Evidence map›Paper›PMID 40159248›Full record

Observational studyJournal of atherosclerosis and thrombosis2025

Cholesterol Uptake Capacity as a Prognostic Marker of Cardiovascular Events for Patients with Coronary Artery Disease.

Yusuke Yoshikawa, Ryuji Toh, Katsuhiro Murakami, Amane Harada, Jeeeun Kim, Yuto Kobayashi, Keiko Miwa, Manabu Nagao, Tatsuro Ishida, Ken-Ichi Hirata and 2 more

Erratum issuedAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of atherosclerosis and thrombosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yusuke YoshikawaDepartment of Biostatistics, National Cerebral and Cardiovascular Center.
Ryuji TohDivision of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine.
Katsuhiro MurakamiCentral Research Laboratories, Sysmex Corporation.
Amane HaradaCentral Research Laboratories, Sysmex Corporation.
Jeeeun KimCentral Research Laboratories, Sysmex Corporation.
Yuto KobayashiCentral Research Laboratories, Sysmex Corporation.
Keiko MiwaCentral Research Laboratories, Sysmex Corporation.
Manabu NagaoDivision of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine.
Tatsuro IshidaDivision of Nursing Practice, Kobe University Graduate School of Health Sciences.
Ken-Ichi HirataDivision of Cardiovascular Medicine, Kobe University Graduate School of Medicine.
Misa TakegamiDepartment of Public Health and Health Policy, The University of Tokyo.
Kunihiro NishimuraDepartment of Biostatistics, National Cerebral and Cardiovascular Center.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimCholesterol uptake capacity (CUC) is a functional assessment of high-density lipoprotein (HDL) and has drawn attention for the risk stratification of atherosclerotic cardiovascular disease (ASCVD). This study evaluated the usefulness of HDL-CUC as a predictive marker for long-term ASCVD events in patients with coronary artery disease (CAD).

methodsThis retrospective observational study included 503 patients with CAD who underwent coronary revascularization. Blood was sampled from the participants within three months before or after index revascularization. The CUC was assayed using a previously reported automated system. The study population was divided into three groups according to the tertiles of CUC levels. The primary outcome was ASCVD events, which were defined as a composite of all-cause death, acute myocardial infarction, stroke, and peripheral artery disease.

resultsA total of 29 events were observed during the follow-up (median 2.8 years). The risk of the primary outcome in the low-CUC group was significantly higher than that in the high-CUC group (3-year incidence: low CUC 8.8% vs. high CUC 4.0%; log-rank p = 0.046). After adjusting for age and sex, the risk in the low-CUC group relative to that in the high-CUC group remained significantly high (hazard ratio 3.17, 95% confidence interval 1.05-9.54, p = 0.040).

conclusionLow CUC in patients with CAD were associated with a higher risk of ASCVD events after coronary revascularization than high CUC levels. The assessment of HDL functionality measured by CUC would be useful for the risk prediction of ASCVD after coronary revascularization.

Indexed as

BiomarkersCholesterolCholesterol, HDLCoronary Artery DiseaseAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentRisk FactorsBiomarkersCholesterolCholesterol, HDLCholesterol efflux capacityCholesterol uptake capacityCoronary artery diseaseFunctionality of high-density lipoproteinHigh-density lipoproteinSecondary prevention

Identifiers

PMID40159248
PMCPMC12416930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.