Evidence map›Paper›PMID 40159157›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Bucillamine-induced Yellow Nail Syndrome with Chylothorax.

Yukari Hisamoto, Yoriyuki Murata, Kazuki Matsuda, Koji Narikiyo, Taiga Kobayashi, Kosei Yonezawa, Keita Murakawa, Kazuki Hamada, Syuichiro Ohata, Toshiaki Utsunomiya and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yukari HisamotoThe Department of Respiratory Medicine, National Hospital Organization Yamaguchi-Ube Medical Center, Japan.
Yoriyuki MurataThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Kazuki MatsudaThe Department of Respiratory Medicine, Japan Community Health care Organization Tokuyama Central Hospital, Japan.
Koji NarikiyoThe Department of Radiology, Graduate School of Medicine, Yamaguchi University, Japan.
Taiga KobayashiThe Department of Radiology, Graduate School of Medicine, Yamaguchi University, Japan.
Kosei YonezawaThe Department of Respiratory Medicine, National Hospital Organization Yamaguchi-Ube Medical Center, Japan.
Keita MurakawaThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Kazuki HamadaThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Syuichiro OhataThe Department of Respiratory Medicine, Japan Community Health care Organization Tokuyama Central Hospital, Japan.
Toshiaki UtsunomiyaThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Yoshikazu YamajiThe Department of Respiratory Medicine, Japan Community Health care Organization Tokuyama Central Hospital, Japan.
Keiji OishiThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Maki Asami-NoyamaThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Nobutaka EdakuniThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Tomoyuki KakugawaThe Department of Pulmonology and Gerontology, Graduate School of Medicine, Yamaguchi University, Japan.
Tsunahiko HiranoThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.
Kazuto MatsunagaThe Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yellow nail syndrome (YNS), a rare condition characterized by thickened yellow nails, lymphedema, and respiratory manifestations, is rarely caused by bucillamine, an anti-rheumatic agent. Respiratory manifestations of YNS include chylothorax in 18.8-22% of patients with pleural effusion. We herein report the first case of bucillamine-induced YNS with chylothorax. Lymphangiography revealed narrowing of the lymphatic vessels and stagnation of the lymphatic fluid, suggesting impaired lymphatic drainage. The chylothorax persisted despite the discontinuation of bucillamine. The present case illustrates that bucillamine can cause irreversible lymphatic impairment and chylothorax.

Indexed as

ChylothoraxYellow Nail SyndromeFemaleHumansLymphographyMiddle Agedbucillaminechylothoraxlymphangiographyyellow nail syndrome

Identifiers

PMID40159157
PMCPMC12508610

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.