Evidence map›Paper›PMID 40158855›Full record

ArticleThe Journal of biological chemistry2025

PEX1

Connor J Sheedy, Soham P Chowdhury, Bashir A Ali, Julia Miyamoto, Eric Z Pang, Julien Bacal, Katherine U Tavasoli, Chris D Richardson, Brooke M Gardner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Connor J SheedyBiomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, California, USA.
Soham P ChowdhuryDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Bashir A AliDepartment of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Julia MiyamotoDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Eric Z PangDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Julien BacalDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Katherine U TavasoliDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Chris D RichardsonDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Brooke M GardnerDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA. Electronic address: brookegardner@ucsb.edu.

Funding

Investigating the mechanisms of peroxisome homeostasisR35GM146784 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Brooke Meghan Gardner · 2022 to 2026
$2.1M
Defining DNA resection and protein localization changes that occur during DSB repairR35GM142975 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI RICHARDSON, CHRIS · 2021 to 2025
$1.9M
Investigating the role of AAA+-ATPases in peroxisome biologyR00GM121880 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GARDNER, BROOKE MEGHAN · 2019 to 2021
$747k
QE-HF-X Mass SpectrometerS10OD026918 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2020 to 2020
$600k
NIGMS NIH HHS R00 GM121880NIGMS NIH HHS R35 GM142975NIGMS NIH HHS R35 GM146784NIH HHS S10 OD026918
6 · The paper itself

Abstract

The PEX1/PEX6 AAA-ATPase is required for the biogenesis and maintenance of peroxisomes. Mutations in HsPEX1 and HsPEX6 disrupt peroxisomal matrix protein import and are the leading cause of peroxisome biogenesis disorders. The most common disease-causing mutation in PEX1 is the HsPEX1

Indexed as

Membrane ProteinsMutation, MissensePeroxisomesProteasome Endopeptidase ComplexProteolysisSaccharomyces cerevisiae ProteinsATPases Associated with Diverse Cellular ActivitiesHEK293 CellsHumansPeroxinsPeroxisome-Targeting Signal 1 ReceptorSaccharomyces cerevisiaeATPases Associated with Diverse Cellular ActivitiesMembrane ProteinsPeroxinsPeroxisome-Targeting Signal 1 ReceptorPEX1 protein, humanPEX6 protein, humanProteasome Endopeptidase ComplexSaccharomyces cerevisiae ProteinsATPases associated with diverse cellular activities (AAA)neurodegenerative diseaseperoxisomeproteasomeprotein assemblyprotein degradationprotein stabilityubiquitin thioesterase (OTUB1)

Identifiers

PMID40158855
PMCPMC12147174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.