Evidence map›Paper›PMID 40158739›Full record

ReviewGastroenterology2025

Artificial Intelligence-Enabled Clinical Trials in Inflammatory Bowel Disease: Automating and Enhancing Disease Assessment and Study Management.

Ryan W Stidham, Louis R Ghanem, Joel G Fletcher, David H Bruining

Abstract readReview
In one paragraph

Review in Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan W StidhamDivision of Gastroenterology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan. Electronic address: ryanstid@med.umich.edu.
Louis R GhanemJohnson & Johnson Innovative Medicine, Spring House, Pennsylvania.
Joel G FletcherDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
David H BruiningDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Funding

Automated Measurement of Bowel Damage Using Enterography Imaging to Predict Clinical Outcomes in Crohn’s Disease.R01DK124779 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STIDHAM, RYAN WILLIAM · 2020 to 2023
$2.1M
NIDDK NIH HHS R01 DK124779
6 · The paper itself

Abstract

Artificial intelligence (AI) will fundamentally improve how we perform clinical trials by addressing issues of standardizing disease scoring, improving the sensitivity and precision of activity and phenotype assessments, and automating laborious and time-consuming study functions. Progress in AI image analysis is quickly proving to replicate expert judgment in endoscopy, histology, and cross-sectional imaging with speed, reproducibility, and reduced bias. However, AI analytics offer the ability to quantify disease characteristics with more detail and precision than human experts. Large language models and generative AI are automating the collection of high-quality data from electronic records and improving our ability to predict patient outcomes. This narrative review will focus on AI tools available today, their expected implementation, and future-facing opportunities for AI to reimagine inflammatory bowel disease clinical trials.

Indexed as

Artificial IntelligenceClinical Trials as TopicInflammatory Bowel DiseasesHumansReproducibility of ResultsArtificial IntelligenceAutomationComputer VisionCrohn's DiseaseDigital TwinInflammatory Bowel DiseaseLarge Language ModelsNatural Language ProcessingUlcerative Colitis

Identifiers

PMID40158739
PMCPMC12350071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.