Evidence map›Paper›PMID 40158087›Full record

Trial reportBMC geriatrics2025

Impaired sleep, depressive symptoms, and pain as determinants of physical activity and exercise intervention adherence: an exploratory analysis of a randomized clinical trial.

Eija Kekkonen, Anette Hall, Riitta Antikainen, Satu Havulinna, Miia Kivipelto, Jenni Kulmala, Tiina Laatikainen, Teemu I Paajanen, Shireen Sindi, Hilkka Soininen and 4 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01041989 (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01041989 naunknown statusnot on this map

Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability

TypeinterventionalSponsorFinnish Institute for Health and WelfareRan2009 to 2025Enrolled1,200ConditionsCognitive Impairment, DementiaArmsNutritional guidance, Exercise, Cognitive training, Reduction of vascular risk factors
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eija KekkonenDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio, FI-70211, Finland. eija.kekkonen@uef.fi.
Anette HallDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio, FI-70211, Finland.
Riitta AntikainenCenter for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland.
Satu HavulinnaDepartment Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Jenni KulmalaDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Tiina LaatikainenDepartment Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Teemu I PaajanenWork Ability and Working Careers, Finnish Institute of Occupational Health, Helsinki, Finland.
Shireen SindiDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Hilkka SoininenDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio, FI-70211, Finland.
Timo StrandbergCenter for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland.
Jaakko TuomilehtoDepartment Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Tiia NganduDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Alina SolomonDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio, FI-70211, Finland.

Funding

European Research Council 804371
6 · The paper itself

Abstract

backgroundPhysical activity (PA) and exercise interventions offer health benefits can reduce dementia risk. However, there might be barriers to engage in PA, such as sleep problems, depressive symptoms and pain, which are common complaints with older adults. We investigated sleep duration, sleep quality, depressive symptoms, and pain at baseline as potential determinants of: (i) adherence to the exercise intervention component of a 2-year multidomain lifestyle intervention; (ii) intervention's effect on PA after 2 years; and (iii) overall PA after 2 years (exploratory analyses).

methodsThe FINGER trial included 1259 individuals at risk for dementia, aged 60-77 years who were randomized (1:1) to a multidomain lifestyle intervention (exercise, diet, cognitive training, vascular risk factor management) or a control (regular health advice) group. Logistic regression analyses were used with exercise adherence (adherent: ≥66% participation) or self-reported PA (active: ≥2 times/week) as outcomes, adjusted for relevant baseline characteristics. Data on PA at baseline and at 2-years were available for 1100 participants.

resultsAdherence to the exercise intervention was less likely with sleep duration < 6 h or ≥ 9 h per night compared with 7-8 h. OR (95% CI) were 0.46 (0.21-0.99) and 0.38 (0.20-0.74), respectively. The intervention group was more likely to be physically active than the control group at two years (OR 1.87, 95% CI 1.36-2.55). This intervention benefit did not significantly vary by baseline sleep duration, depressive symptoms, or pain (p > 0.3 for all interactions). Regardless of randomization group, those sleeping < 6 h were less likely to be physically active at two years, compared with participants sleeping 7-8 h (OR 0.36, 95% CI 0.18-0.72). Depressive symptoms or pain were not related to PA at two years.

conclusionsOlder adults with sleep problems, depressive symptoms, or pain may benefit from lifestyle interventions. However, both short and long sleep duration can pose barriers to engaging in exercise intervention and should be carefully considered when designing strategies to promote PA among older populations at risk for dementia.

trial registrationThe FINGER trial was registered at ClinicalTrials.gov with identifier NCT01041989 on 04/01/2010.

Indexed as

DepressionExerciseExercise TherapyMotor ActivityPainPatient ComplianceSleep Wake DisordersAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedAdherenceExerciseLifestyle interventionMoodPainPhysical activitySleep

Identifiers

PMID40158087
PMCPMC11954347

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.