Evidence map›Paper›PMID 40158043›Full record

ArticleScientific reports2025

PVA and PVP nanofibers combined with Helichrysum italicum oil preserve skin cell interactions, elasticity and proliferation.

Diletta Serra, Giuseppe Garroni, Sara Cruciani, Donatella Coradduzza, Aleksei Pashchenko, Evzen Amler, Giorgio Pintore, Pietro Parisse, Rosanna Satta, Fernanda Martini and 4 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Diletta SerraDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Giuseppe GarroniDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Sara CrucianiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Donatella CoradduzzaDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Aleksei PashchenkoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Evzen AmlerUniversity Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czech Republic.
Giorgio PintoreDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
Pietro ParisseInstitute of Materials (IOM-CNR), Area Science Park, 34149, Basovizza, Trieste, Italy.
Rosanna SattaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
Fernanda MartiniDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Mauro TognonDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Antonio BrunettiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Carlo VenturaLaboratory of Molecular Biology and Stem Cell Engineering - Eldor Lab Istituto Nazionale Biostrutture e Biosistemi, Via Di Corticella 183, 40128, Bologna, Italy.
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy. mmaioli@uniss.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of electrospun nanofibers with suitable properties to promote wound healing is an advantage in developing non-invasive skin treatments. We showed the potential application of Polyvinyl acetate (PVA) and Polyvinylpyrrolidone (PVP) combined with Helichrysum italicum oil (HO) in wound healing. During this process, Tight junctions (TJs) play a crucial role in maintaining skin integrity. TJs are intercellular junctions composed of a variety of transmembrane proteins, including Occludin (OCLN), observed also in migrating epithelial cells. Changes in OCLN expression affect epidermal permeability, indicating an active role in the healing process. Within this context, we studied the OCLN expression during healing after scratch assay on Keratinocytes (HaCaT), by a confocal microscopic analysis. In addition, we evaluated the effect of treatment after scratch on cell elasticity by Atomic Force Microscopy (AFM) analysis. All results show a positive trend in cell proliferation and viability on HaCaT treated with functionalized nanofibers. These results were confirmed by the expression of genes involved in the early stages of the regenerative process. Understanding the cell mechanisms involved in skin changes during repair process would allow future application of nanomaterials combined with HO in vivo.

Indexed as

Cell CommunicationNanofibersPlant OilsPolyvinyl AlcoholPovidoneSkinCell LineCell ProliferationCell SurvivalElasticityHaCaT CellsHumansKeratinocytesMicroscopy, Atomic ForceOccludinWound HealingOccludinPlant OilsPolyvinyl AlcoholPovidoneBioactive moleculesCellular mechanismKeratinocytesNanofibersRegenerative medicineTissue regenerationWound healing

Identifiers

PMID40158043
PMCPMC11954863

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.