Evidence map›Paper›PMID 40157920›Full record

ArticleNature communications2025

Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics.

Federica Fermani, Simon Chang, Ylenia Mastrodicasa, Christian Peters, Louise Gaitanos, Pilar L Alcala Morales, Charu Ramakrishnan, Karl Deisseroth, Rüdiger Klein

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federica FermaniDepartment of Molecules - Signaling - Development, Max-Planck Institute for Biological Intelligence, Martinsried, Germany.
Simon ChangCellular Neurobiology, Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0002-7276-0629
Ylenia MastrodicasaDepartment of Molecules - Signaling - Development, Max-Planck Institute for Biological Intelligence, Martinsried, Germany.ORCID http://orcid.org/0009-0009-4849-9270
Christian PetersDepartment of Molecules - Signaling - Development, Max-Planck Institute for Biological Intelligence, Martinsried, Germany.ORCID http://orcid.org/0000-0001-5033-6571
Louise GaitanosDepartment of Molecules - Signaling - Development, Max-Planck Institute for Biological Intelligence, Martinsried, Germany.
Pilar L Alcala MoralesDepartment of Molecules - Signaling - Development, Max-Planck Institute for Biological Intelligence, Martinsried, Germany.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3474-6332
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9440-3967
Rüdiger KleinDepartment of Molecules - Signaling - Development, Max-Planck Institute for Biological Intelligence, Martinsried, Germany. ruediger.klein@bi.mpg.de.ORCID http://orcid.org/0000-0002-3109-0163

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central amygdala (CeA) plays a crucial role in defensive and appetitive behaviours. It contains genetically defined GABAergic neuron subpopulations distributed over three anatomical subregions, capsular (CeC), lateral (CeL), and medial (CeM). The roles that these molecularly- and anatomically-defined CeA neurons play in appetitive behavior remain unclear. Using intersectional genetics in mice, we found that neurons driving food or water consumption are confined to the CeM. Separate CeM subpopulations exist for water only versus water or food consumption. In vivo calcium imaging revealed that CeM

Indexed as

AmygdalaCentral Amygdaloid NucleusDrinkingEatingAnimalsAppetitive BehaviorFeeding BehaviorFemaleGABAergic NeuronsMaleMiceMice, Inbred C57BLMice, TransgenicParabrachial Nucleus

Identifiers

PMID40157920
PMCPMC11954953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.