ArticleTranslational psychiatry2025
Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Balancing consistency and flexibility: exploring trait and state optimism in rats using the cognitive judgement bias test.Frontiers in veterinary science · 2026Article
- Integrating behaviour, physiology, and immune response to social stress in fish.Frontiers in endocrinology · 2026Review
- Psychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates.Pituitary · 2025Article
- A functional framework for a comprehensive study of welfare in fishes.Proceedings. Biological sciences · 2025Review
- Unexpected appetitive events promote positive affective state in juvenile European sea bass.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive judgement bias in decision-making under ambiguity occurs both in animals and humans, with some individuals interpreting ambiguous stimulus as positive (optimism) and others as negative (pessimism). We hypothesize that judgement bias is a personality trait and that individuals with a pessimistic bias would be more reactive to stressors and therefore more susceptible to stress-related diseases than optimistic ones. Here, we show that zebrafish judgment bias is a consistent behavioral trait over time, and that pessimistic and optimistic fish express phenotype-specific neurogenomic responses to stress. Furthermore, both phenotypes show differential activation of the hypothalamic-pituitary-interrenal axis in response to chronic stress, suggesting that optimists have a lower stress reactivity. Accordingly, optimists seem to be more resilient to disease than pessimists, as shown by a lower tumorigenesis in a zebrafish melanoma line [Tg(mtifa:HRAS-GFP)]. Together these results indicate that judgement bias is paralleled by differences in the stress response with implications for disease resilience.
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