Evidence map›Paper›PMID 40157910›Full record

ArticleCell death & disease2025

Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy.

Lihua Mo, Min Deng, Ragini Adhav, Yuni Chan, Josh Haipeng Lei, Sek Man Su, Xin Zhang, Tingting An, Jianlin Liu, Jianjie Li and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lihua MoCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Min DengCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Ragini AdhavCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Yuni ChanCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID http://orcid.org/0000-0001-6095-3565
Josh Haipeng LeiCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID http://orcid.org/0000-0002-2058-8054
Sek Man SuCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Xin ZhangCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Tingting AnCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Jianlin LiuCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Jianjie LiCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Xiaodong ShuCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Jun XuCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Yuqing WangCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Lin ChenLaboratory of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, China.ORCID http://orcid.org/0000-0001-7764-9412
Yan-Gao ManDepartment of Pathology, Hackensack Meridian School of Medicine, Nutley, NJ, USA.
Ning-Yi ShaoCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID http://orcid.org/0000-0003-4231-828X
Tingxiu XiangChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Chu-Xia DengCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China. cxdeng@um.edu.mo.ORCID http://orcid.org/0000-0001-8033-3902
Xiaoling XuCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China. xiaolingx@um.edu.mo.ORCID http://orcid.org/0000-0002-0852-0225

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer initiation and progression are driven by various oncogenic factors and their effects on the surrounding microenvironments. Through integrative analysis of ChIP-sequencing and RNA-sequencing with fast proliferating mammary epithelial cells from pregnant Brca1

Indexed as

Breast NeoplasmsDrug Resistance, NeoplasmHistone-Lysine N-MethyltransferaseImmunotherapyAnimalsCell Line, TumorFemaleHumansMiceProgrammed Cell Death 1 ReceptorPyridonesPyrimidinonesSignal TransductionTumor MicroenvironmentHistone-Lysine N-MethyltransferaseProgrammed Cell Death 1 ReceptorPyridonesPyrimidinonesSMYD3 protein, humantrametinib

Identifiers

PMID40157910
PMCPMC11954966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.