Evidence map›Paper›PMID 40157650›Full record

Trial reportJournal of substance use and addiction treatment2025

Non-adherence to treatment and concurrent opioid use among people on methadone maintenance treatment using methamphetamine in Vietnam.

Nguyen Bich Diep, Nguyen Thu Trang, Do Duc Huy, Hoang Thi Hai Van, Thai Thanh Truc, Do Van Dung, Michael J Li, Steve J Shoptaw, Li Li, Le Minh Giang

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of substance use and addiction treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706624 (Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706624 nacompletednot on this map

Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

TypeinterventionalSponsorHanoi Medical UniversityRan2021 to 2025Enrolled667ConditionsMethamphetamine Abuse, Opioid-use Disorder, HIV SeropositivityArmsContingency management (12 weeks), Contingency management (6 weeks), SMS reminders, Matrix only, Matrix + Contingency management
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nguyen Bich DiepCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Hanoi, Viet Nam.
Nguyen Thu TrangCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Hanoi, Viet Nam.
Do Duc HuyCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Hanoi, Viet Nam.
Hoang Thi Hai VanCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Hanoi, Viet Nam.
Thai Thanh TrucUniversity of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam.
Do Van DungUniversity of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam.
Michael J LiCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.
Steve J ShoptawCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, USA.
Li LiDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, USA.
Le Minh GiangCenter for Training and Research on Substance Use & HIV, Hanoi Medical University, Hanoi, Viet Nam. Electronic address: leminhgiang@hmu.edu.vn.

Funding

Screen, Treat and Retain People with Primary Meth Use Disorder at MMT Clinics (STAR-OM+)R01DA050486 · NIDA · HANOI MEDICAL UNIVERSITY · PI LE, GIANG M, SHOPTAW, STEVEN J · 2020 to 2024
$2.3M
Trajectories of socially regulated gene expression, methamphetamine use, and viral load among HIV-positive men who have sex with men (MSM) receiving contingency managementK01DA051329 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, MICHAEL JONATHAN · 2021 to 2025
$947k
NIDA NIH HHS K01 DA051329NIDA NIH HHS R01 DA050486
6 · The paper itself

Abstract

introductionThe global rise of concurrent use of opioids and methamphetamine presents challenges to stable methadone maintenance treatment (MMT). We assessed non-adherence to treatment and concurrent opioid use, along with associated factors, among people on MMT using methamphetamine in Vietnam.

methodsThis analysis utilized baseline data from a randomized clinical trial designed to investigate the effectiveness of various combinations of behavioral evidence-based interventions for methamphetamine use among patients on MMT in Vietnam (STAR-OM R01DA050486). We used data from 498 participants on MMT who self-reported using methamphetamine in the past 30 days and had been in MMT treatment for at least three months. The study determined adherence to MMT through medical record review and assessed concurrent opioid use via urine testing and documented test results in medical records.

resultsWithin the last three months, 145 (29.1 %) did not adhere to MMT, and 212 (42.6 %) concurrently used opioids. Non-adherence to MMT were strongly associated with living at a considerable distance from the clinic (aOR = 1.80, 95 % CI: 1.10-2.90), being HIV positive (aOR = 0.51, 95 % CI: 0.27-0.97), and were marginally associated with using methamphetamine to reduce emotional distress (aOR = 1.56, 95 % CI: 0.99-2.45). Concurrent opioid use was associated with receiving treatment at clinics established during the scale-up period (aOR = 1.80, 95 % CI: 1.13-2.87), an extended duration of treatment at current clinics (aOR = 0.98, 95 % CI: 0.97-0.99), male gender (aOR = 2.09, 95 % CI: 1.05-4.13), and ever injecting methamphetamine (aOR = 1.98, 95 % CI: 1.13-3.46), besides MMT non-adherence (aOR = 2.71, 95 % CI: 1.72-4.29).

conclusionNon-adherence to MMT and concurrent opioid use are prevalent among methamphetamine-using patients on methadone in Vietnam. Alongside well-documented factors influencing methadone program, the rise in methamphetamine adds further complexity to these challenges. Future intervention strategies must address both the underlying issues and methamphetamine use behaviors to effectively improve treatment outcomes.

trial registrationNCT04706624. Registered 13 January 2021. https://clinicaltrials.gov/ct2/show/NCT04706624.

Indexed as

Amphetamine-Related DisordersMethadoneMethamphetamineOpiate Substitution TreatmentOpioid-Related DisordersAdultAnalgesics, OpioidFemaleHumansMaleMedication AdherenceMiddle AgedVietnamAnalgesics, OpioidMethadoneMethamphetamineConcurrent opioid useMethadone non-adherenceMethamphetamine co-useMMT

Identifiers

PMID40157650
PMCPMC12068964

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.