ArticleInternational journal of pharmaceutics2025
Development and adhesion evaluation of transdermal rotigotine patches utilizing 3D-printed skin-mimicking substrate, solid-state NMR, and ATR-FTIR techniques.
Article in International journal of pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Comprehensive design and characterization of pH-gradient-loaded donkey-milk exosomes for oral octreotide delivery: A bench-to-in silico roadmap.International journal of pharmaceutics · 2026Article
- Konjac Glucomannan as a Gel-Forming Biopolymer for Transdermal Drug Delivery: Properties, Formulation Strategies, and Translational Challenges.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Transdermal rotigotine patches, used to treat parkinson's disease, often face challenges in maintaining adequate adhesion, which is crucial for effective drug delivery. Adhesion performance is influenced by environmental conditions such as humidity and temperature, as well as skin characteristics like wrinkles and micro-delaminations that vary with age and sex. Standard adhesion tests using stainless steel (SS) substrates do not accurately mimic human skin, leading to overestimated adhesion strength. This study developed rotigotine matrix transdermal formulations with silicone pressure sensitive adhesive (PSA) and evaluated their adhesion properties at 32 ± 1°C and 75 ± 5 % RH in a stability chamber. Moisture uptake over 24 h was measured using solid-state nuclear magnetic resonance (SSNMR) spectroscopy and attenuated total reflectance-fourier transform infrared- (ATR-FTIR) spectroscopy. Adhesion tests, including probe tack and peel, were performed on SS and 3D-printed acrylonitrile butadiene styrene (ABS) substrates designed with micro-delaminations and wrinkles to simulate skin conditions. In vitro permeation testing (IVPT) studies demonstrated a flux of 10.48 ± 0.61 and 10.03 ± 0.57 μg/h/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.