Evidence map›Paper›PMID 40157354›Full record

ArticleStem cell reports2025

ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons.

Jacob A Klickstein, Michelle A Johnson, Pantelis Antonoudiou, Jamie Maguire, Joao A Paulo, Steve P Gygi, Chris Weihl, Malavika Raman

Abstract readPublished Erratum
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jacob A Klickstein
Michelle A Johnson
Pantelis Antonoudiou
Jamie Maguire
Joao A Paulo
Steve P Gygi
Chris Weihl
Malavika Raman

Funding

“Regulation of Protein Quality Control by the VCP AAA-ATPase”R01GM127557 · NIGMS · TUFTS UNIVERSITY BOSTON · PI Malavika Raman · 2018 to 2026
$3.5M
Investigating the impact of p97 mutation in Amyotrophic Lateral SclerosisR21NS123631 · NINDS · TUFTS UNIVERSITY BOSTON · PI RAMAN, MALAVIKA · 2022 to 2023
$454k
NIGMS NIH HHS R01 GM127557NINDS NIH HHS R21 NS123631
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40157354
PMCPMC12143151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.