Evidence map›Paper›PMID 40157353›Full record

ArticleCurrent biology : CB2025

Animal septins contain functional transmembrane domains.

Jenna A Perry, Michael E Werner, Shizue Omi, Bryan W Heck, Paul S Maddox, Manos Mavrakis, Amy S Maddox

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. TaggingbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jenna A PerryDepartment of Biology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jenna_perry@unc.edu.
Michael E WernerDepartment of Biology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Shizue OmiInstitut Fresnel, CNRS UMR7249, Aix Marseille University, Centrale Med, 13013 Marseille, France.
Bryan W HeckDepartment of Biology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Paul S MaddoxDepartment of Biology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Manos MavrakisInstitut Fresnel, CNRS UMR7249, Aix Marseille University, Centrale Med, 13013 Marseille, France.
Amy S MaddoxDepartment of Biology, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: asm@unc.edu.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Mechanisms of cell shape change in cytokinesisR35GM144238 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amy Shaub Maddox · 2022 to 2026
$2.4M
Molecular, cellular, and developmental mechanisms of septin disease allelesF32GM143910 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERRY, JENNA ANN · 2022 to 2022
$68k
NIGMS NIH HHS F32 GM143910NIGMS NIH HHS R35 GM144238NIH HHS P40 OD010440
6 · The paper itself

Abstract

Septins are a highly conserved family of proteins that form palindromic hetero-oligomeric rods, which anneal into non-polar filaments. Via association with the plasma membrane, septin filaments recognize micron-scale membrane curvature, create diffusion barriers, and regulate cell morphogenic events via scaffolding other cytoskeletal polymers (i.e., filamentous actin [F-actin] and microtubules) and biochemical regulators of cell division, cell migration, and polarity establishment.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneSeptinsAmino Acid SequenceAnimalsProtein DomainsCaenorhabditis elegans ProteinsSeptinsC. eleganscytoskeletonphylogenyprimatesubcellular localizationtissue morphogenesis

Identifiers

PMID40157353
PMCPMC12751117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.