ArticleJournal of psychosomatic research2025
Incident mental disorders after breast cancer: A matched population-based cohort.
Article in Journal of psychosomatic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and Influencing Factors of Anxiety and Depression in Patients With Breast Cancer: A Meta-Analysis.Actas espanolas de psiquiatria · 2026Pooled it
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo assess the risk of mental disorders and contributing factors of depression in breast cancer survivors, as well as to estimate the risk of death.
methodsA total of 20,440 women diagnosed with breast cancer between 1997 and 2017 were identified in the Utah Cancer Registry and matched to a general population of women without cancer. To assess the risk of mental disorders and death following breast cancer, hazard ratios (HRs) and 99 % confidence intervals (CI) were estimated using Cox proportional-hazards models overall, within 2, > 2 to 5, and > 5-years of follow-up.
resultsCompared with women without cancer, breast cancer survivors had an elevated risk of depression notably within 2 years of follow-up for depression (HR 2.64, 99 %CI 2.43, 2.87), anxiety (HR 2.89, 99 %CI 2.66, 3.15), bipolar (HR 1.85, 99 %CI 1.45, 2.37), alcohol (HR 1.88, 99 %CI 1.43, 2.46), and substance-related disorders (HR 1.95, 99 %CI 1.59, 2.39). Although the risks were attenuated compared to the immediate follow-up, the burden of alcohol- and substance-disorders persisted within 5 and depression and anxiety >5 years post cancer. Breast cancer survivors diagnosed with substance-related disorders within 2 years of cancer had a 2.3-fold higher risk of death (HR 2.28, 99 % CI 1.72, 3.03) compared to those without during the same time period. Depression predictors included obesity, ≥2 comorbidities, chemotherapy, or being separated.
conclusionCompared with women without cancer, breast cancer survivors had an elevated risk of multiple mental disorders. The risk of death was notably increased among breast cancer survivors with substance-related disorders.
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