Evidence map›Paper›PMID 40157021›Full record

ArticleVision research2025

Scleral ultrastructure in young rhesus monkeys: A stereological approach.

Suharsha Paidimarri, Baskar Arumugam, Li-Fang Hung, Earl L Smith, Alan R Burns, Lisa A Ostrin

Abstract read
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In one paragraph

Article in Vision research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Suharsha PaidimarriUniversity of Houston, College of Optometry, 4401 Martin Luther King Blvd, Houston, TX 77204, USA.
Baskar ArumugamUniversity of Houston, College of Optometry, 4401 Martin Luther King Blvd, Houston, TX 77204, USA.
Li-Fang HungUniversity of Houston, College of Optometry, 4401 Martin Luther King Blvd, Houston, TX 77204, USA.
Earl L SmithUniversity of Houston, College of Optometry, 4401 Martin Luther King Blvd, Houston, TX 77204, USA.
Alan R BurnsUniversity of Houston, College of Optometry, 4401 Martin Luther King Blvd, Houston, TX 77204, USA.
Lisa A OstrinUniversity of Houston, College of Optometry, 4401 Martin Luther King Blvd, Houston, TX 77204, USA. Electronic address: Lostrin@central.uh.edu.

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
Optically Induced AnisometropiasR01EY003611 · NEI · UNIVERSITY OF HOUSTON · PI Lisa A Ostrin · 1985 to 2026
$11.1M
Light, near work, and ocular remodeling and during emmetropization and myopia development in childrenR01EY030193 · NEI · UNIVERSITY OF HOUSTON · PI Lisa A Ostrin, Jason Porter · 2019 to 2026
$2.7M
NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY003611NEI NIH HHS R01 EY030193
6 · The paper itself

Abstract

The sclera provides mechanical support to the globe and plays a key role in maintenance of ocular structural integrity. Evidence shows that scleral remodeling contributes to biomechanical weakening, increasing the risk of pathologies, such as glaucoma and posterior staphyloma in high myopia. A precise characterization of normal regional ultrastructure is needed for a better understanding of scleral remodeling. The purpose of this study was to develop and implement a stereological analysis method to characterize scleral ultrastructure in healthy young rhesus monkey eyes. Monkeys (N = 4 eyes) first underwent normal emmetropization in a primate nursery. At 150 days of age, scleral tissue was collected in 1 mm

Indexed as

ScleraAnimalsFibroblastsMacaca mulattaMicrofibrilsMicroscopy, Electron, TransmissionCollagen fibrilsFibrillin microfibrilsFibroblastsScleraUltrastructure

Identifiers

PMID40157021
PMCPMC12884975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.