Evidence map›Paper›PMID 40156888›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Choline Chloride/Urea - Promoted Iodocyclization of 3-Alkynylthiophene-2-carboxamides: A Green Synthesis of 4-Iodo-7H-thieno[2,3-c]pyran-7-imines and Their Coupling Reactions in Deep Eutectic Solvents.

Raffaella Mancuso, Patrizio Russo, Ida Ziccarelli, Melania Lettieri, Angela Altomare, Matteo Tiecco, Edoardo Mosconi, Tommaso Moretti, Bartolo Gabriele

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raffaella MancusoLaboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Arcavacata di Rende, Italy.ORCID https://orcid.org/0000-0001-7514-6096
Patrizio RussoLaboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Arcavacata di Rende, Italy.ORCID https://orcid.org/0000-0003-3225-0322
Ida ZiccarelliLaboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Arcavacata di Rende, Italy.ORCID https://orcid.org/0000-0003-3591-0787
Melania LettieriLaboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Arcavacata di Rende, Italy.ORCID https://orcid.org/0000-0002-2554-9011
Angela AltomareInstitute of Crystallography, National Research Council, Bari, Italy.ORCID https://orcid.org/0000-0002-8727-6610
Matteo TieccoSchool of Pharmacy, ChIP Research Center, University of Camerino, Camerino, Italy.ORCID https://orcid.org/0000-0002-1867-421X
Edoardo MosconiComputational Laboratory for Hybrid and Organic Photovoltaics Istituto CNR di Scienze e Tecnologie Chimiche (SCITEC-CNR) c/o Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0001-5075-6664
Tommaso MorettiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Bartolo GabrieleLaboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Arcavacata di Rende, Italy.ORCID https://orcid.org/0000-0003-4582-1489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A green approach to a previously unknown class of iodine-containing heterocycles, namely 4-iodo-7H-thieno[2,3-c]pyran-7-imines, by iodocyclization of readily available 3-alkynylthiophene-2-carboxamides in a deep eutectic solvent (DES) as both solvent and promoter, has been developed. We have found that, while the reaction with I

Indexed as

alkynesamidesdeep eutectic solventsfused heterocyclesiodocyclization

Identifiers

PMID40156888
PMCPMC12080309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.