ArticleNucleic acids research2025
Self-contained G-quadruplex/hemin DNAzyme: a superior ready-made catalyst for in situ imaging analysis.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Decoding the Spatiotemporal Logic of Cellular Senescence through Multimodal Exosomal miRNA Integration.JACS Au · 2026Article
- Synergistic antioxidant and gene supplementation for high-efficacy retinitis pigmentosa therapy.Science advances · 2026Article
- High Sensitivity Cardiac Troponin I Detection via MP-Locked Aptamer and Multimeric DNAzyme-Coupled Hyperbranched Hybridization Chain Reaction.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Advances in DNAzyme Selection, Molecular Engineering and Biomedical Applications.International journal of molecular sciences · 2026Review
- Rational redesign of high-activity G-quadruplex DNAzyme through flanking and looping of nucleobases.Scientific reports · 2026Article
- Advances in nucleic acid probe-based detection of gene point mutations: a review.Frontiers in chemistry · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The G4 DNAzyme holds significant potential for applications in bioanalysis and determination owing to its peroxidase mimetic activity and DNA programmability. However, its clinical practicability is constrained by limited catalytic activity and supplementary assembly requirements, attributed to weak π-π stacking, deficient active-site components, and ion-dependent assembly mechanisms. Thus, we constructed a highly active self-contained intramolecular G4/hemin DNAzyme through the direct covalent cross-linking of catalytic core components involving the hemin prosthetic group, G4 pocket, and distal ligand-like assistant nucleotide (adenine or cytosine). Detailed investigations of the catalytic efficiency and mechanism confirmed the formation of a compact catalytic active center through covalent bonding, which enhanced the catalysis to a stage comparable to that of horseradish peroxidase in localized surroundings. The superior ready-made catalytic modularity with programmability enabled the highly sensitive in situ imaging analysis of HER2 protein in breast cancer specimens. This study provides a powerful tool for disease marker imaging detection with high sensitivity and immediate availability.
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Registered trials
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