Evidence map›Paper›PMID 40156840›Full record

ArticleJournal of medicinal chemistry2025

From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in

Marie Thiemann, Moritz Zimmermann, Christina Diederich, Huilin Zhan, Mikhail Lebedev, Jakob Pletz, Janosch Baumgarten, Maria Handke, Mathias Müsken, Rolf Breinbauer and 6 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marie ThiemannInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.ORCID 0009-0009-1111-0671
Moritz ZimmermannInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.ORCID 0009-0005-8293-7255
Christina DiederichHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Huilin ZhanHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.ORCID 0009-0002-7304-9174
Mikhail LebedevDepartment Biologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.ORCID 0000-0001-7461-0977
Jakob PletzInstitute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.
Janosch BaumgartenInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.ORCID 0009-0003-6748-6316
Maria HandkeInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.ORCID 0009-0007-7175-3615
Mathias MüskenHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Rolf BreinbauerInstitute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.ORCID 0000-0001-6009-7359
Gabriela Krasteva-ChristFaculty of Medicine, Institute for Anatomy and Cell Biology & Center for Gender-specific Biology and Medicine (CGBM), Saarland University, Kirrbergerstr. 100, 66424 Homburg, Saar, Germany.ORCID 0000-0002-0113-521X
Esther ZaninDepartment Biologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
Martin EmptingHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Matthias SchiedelInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.ORCID 0000-0001-7365-3617
Conrad KunickInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.
Wulf BlankenfeldtHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.ORCID 0000-0001-9886-9668

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human pathogen

Indexed as

Anti-Bacterial AgentsPseudomonas aeruginosaPyocyanineRaloxifene HydrochlorideBacterial ProteinsHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsBacterial ProteinsPyocyanineRaloxifene Hydrochloride

Identifiers

PMID40156840
PMCPMC11998002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.