Evidence map›Paper›PMID 40156769›Full record

SynthesisNeuroradiology2025

Transradial versus transfemoral access in diagnostic cerebral angiography: a comprehensive systematic review and meta-analysis of clinical outcomes and complications.

Abdelrahman M Hamouda, Tasnim El Gazar, Mohamed Ahmed Ali, Saroj Kumar Jha, Mark Cwajna, Nicholas Kendall, Mohamed Derhab, Sherief Ghozy, Zach Pennington, Rahul Kumar and 3 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Dual Artery Compression for Patent Hemostasis and Prevention of Radial Artery Occlusion: The Quebec TerryCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Abdelrahman M Hamouda *Department of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. Hamouda.abdelrahman@mayo.edu.ORCID http://orcid.org/0009-0007-3609-7229
Tasnim El Gazar *Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Mohamed Ahmed AliQena Faculty of Medicine, South Valley University, Qena, Egypt.
Saroj Kumar JhaDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Mark CwajnaDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Nicholas KendallDepartment of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Mohamed DerhabDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Sherief GhozyDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Zach PenningtonDepartment of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Rahul KumarDepartment of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Kogulavadanan ArumaithuraiDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Waleed BrinjikjiDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
David F KallmesDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnostic Cerebral Angiography (CA) is a relatively common procedure that provides detailed evaluation of the brain's blood vessels. With the growing preference for Transradial artery (TRA) access over Transfemoral artery (TFA) access, our review aims to compare clinical outcomes and complications between these two approaches.

methodsWe carried out a systematic review using PubMed, Embase, Web of Science, Scopus databases, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Inclusion was limited to studies that exclusively compared TRA versus TFA approaches for cerebral diagnostic purposes.

resultsOur study included 27 studies encompassing a total of 12,806 patients. The TRA arm comprised 6,284 patients with a median age of 57.9 years, and 46.4% were male. The TFA arm included 6,522 patients with a median age of 59.0 years, and 44.8% were male. Our analysis revealed that the TFA group had a higher successful Cerebral Angiography (CA) rate (OR = 0.62, p = 0.03), and lower crossover rate (OR: 2.85, p < 0.01) compared to the TRA group. However, the TRA group demonstrated a significantly lower rate of total complications (OR: 0.52, p < 0.01) and shorter hospital length of stay (LOS) in hours ([MD]: -33.25, p < 0.001) compared to the TFA group. There were no significant differences between groups in terms of procedural metrics.

conclusionOur review highlighted the superiority of the transfemoral artery approach in terms of success rates and lower crossover rates. However, transradial artery access may be preferred due to its association with lower complication rates and shorter hospital stays, aligning with patient-centered outcomes.

Indexed as

Cerebral AngiographyFemoral ArteryRadial ArteryHumansCerebral angiographyTransfemoralTransradial

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.