Evidence map›Paper›PMID 40156758›Full record

ArticleNeurology and therapy2025

Endovascular Treatment in Patients with Large Vessel Occlusion Stroke of Different Mechanisms.

Zhiyuan Feng, Ming Yang, Aoming Jin, Ning Ma, Feng Gao, Dapeng Mo, Xiaojuan Liu, Fangyuan Zhang, Xinchen Li, Yimeng Li and 9 more

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Article in Neurology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Zhiyuan Feng *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Ming Yang *China National Clinical Research Center for Neurological Diseases, Beijing, China.
Aoming JinChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Ning MaChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Feng GaoChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Dapeng MoChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Xiaojuan LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Fangyuan ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Xinchen LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Yimeng LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Qi ChuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Jing XueDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Aichun ChengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Jinxi LinDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Hao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Xia MengChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Zhongrong MiaoChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China. yongjunwang@ncrcnd.org.cn.
Jie XuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China. xujie@ncrcnd.org.cn.

Funding

National Key R&D Program of China 2022YFC2502400National Key R&D Program of China 2022YFC2502403National Natural Science Foundation of China 82301651National Natural Science Foundation of China 82371294
6 · The paper itself

Abstract

introductionAcute ischemic stroke with large vessel occlusion (AIS-LVO) is mainly caused by in situ thrombosis (IST), artery-to-artery embolism (AAE), and cardioembolism (CE). The clinical characteristics and prognosis of each mechanism are unclear in a real-world scenario.

methodsWe retrospectively analyzed patients with AIS-LVO who underwent endovascular treatment (EVT) between April 2023 and August 2024. Patients were classified according to three mechanisms. This study aimed to compare the clinical characteristics, lab results, EVT procedural factors, and prognosis of patients with AIS-LVO with three different mechanisms. The modified Rankin Scale (mRS) score at 3 months was the primary outcome, which was analyzed by ordinal logistic regression.

resultsAmong 162 patients included, IST (n = 81) was the most common mechanism, followed by CE (n = 41) and AAE (n = 40). Patients with CE showed more severe initial symptoms and the highest rate of intracranial hemorrhage. Patients with IST were associated with more rapid progression, more posterior circulation involvement, and higher inflammatory profile. Patients with AAE experienced a longer procedural time and had a higher rate of symptomatic intracranial hemorrhage (sICH). Although patients with IST and AAE more often required stenting, no significant difference in the rate of successful recanalization was found. The rates of mRS distribution (p = 0.24), and favorable outcomes at 3 months (p = 0.36) did not differ among the three groups. However, a trend towards better outcomes in the CE group was noted. On multivariable logistic regression, age (odds ratio, 0.97, 95% confidence interval, 0.95-1.00), pre-EVT National Institutes of Health Stroke Scale (NIHSS) (odds ratio, 0.94, 95% confidence interval, 0.89-0.98), and sICH (odds ratio, 0.33, 95% confidence interval, 0.12-0.95) could independently predict a favorable shift in mRS distribution. We failed to find that the mechanism was a predictor of the outcome.

conclusionsThe functional outcomes of patients with AIS-LVO were similar among different mechanisms, despite the sICH being much higher in patients with AAE. The optimal management for AIS-LVO with different mechanisms requires further research.

Indexed as

Acute ischemic strokeEndovascular treatmentLarge vessel occlusion

Identifiers

PMID40156758
PMCPMC12255604

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