Evidence map›Paper›PMID 40156744›Full record

ArticleBulletin of experimental biology and medicine2025

Influence of the Breast Tumor Stromal Fibroblasts on Immunological Processes In Vitro.

R Yu Saryglar, A Yu Lupatov, I V Vakhrushev, S Sh Karshieva, O A Bystrykh, A V Kuprin, K N Yarygin

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R Yu SaryglarInstitute of Biomedical Chemistry, Moscow, Russia. roza_saryglar@mail.ru.
A Yu LupatovInstitute of Biomedical Chemistry, Moscow, Russia.
I V VakhrushevInstitute of Biomedical Chemistry, Moscow, Russia.
S Sh KarshievaN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
O A BystrykhA. V. Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
A V KuprinA. V. Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
K N YaryginInstitute of Biomedical Chemistry, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of stromal cell cultures isolated from breast cancer tissue on the differentiation and maturation of dendritic cells and proliferation of lymphocytes were studied in vitro. The derived cultures had the fibroblast-like morphology and carried mesenchymal markers CD73 and CD90 in the absence of epithelial (CD326, CD24) and macrophage (CD68) markers. The cells also expressed CD44, CD10, and CD29 and had low levels of HLA-ABC expression. Intracellular expression of fibroblast activation protein (FAP), tenascin C, and α-SMA indicated their activated state and stromal origin. Analysis of the functional properties of the cells revealed their ability to suppress differentiation of dendritic cells from monocytes, as well as the proliferation of T lymphocytes. However, they had no significant effect on DC maturation. The results demonstrate that fibroblasts in the tumor stroma of breast cancer may have a suppressive effect on important mechanisms of the adaptive immunity and can be involved in the process of tumor escape from the immunological control.

Indexed as

Breast NeoplasmsCancer-Associated FibroblastsFibroblastsStromal Cells5'-NucleotidaseActinsCell DifferentiationCell ProliferationDendritic CellsEndopeptidasesFemaleFibroblast Activation Protein AlphaGelatinasesGPI-Linked ProteinsHumansHyaluronan Receptors5'-NucleotidaseACTA2 protein, humanActinsEndopeptidasesFibroblast Activation Protein AlphaGelatinasesGPI-Linked ProteinsHyaluronan ReceptorsMembrane ProteinsNT5E protein, humanSerine EndopeptidasesTenascinThy-1 AntigensTNC protein, humanbreast cancerdendritic cellsimmunosuppressionT lymphocytestumor stroma fibroblasts

Identifiers

PMID40156744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.