Evidence map›Paper›PMID 40156740›Full record

ArticleJapanese journal of radiology2025

Clinical significance of splenic switch-off in adenosine triphosphate

Kentaro Ohara, Naoto Kawaguchi, Hideki Okayama, Hitomi Ueda, Ryutaro Ueno, Kuniaki Hirai, Yuki Tanabe, Megumi Matsuda, Tomoyuki Kido, Takeshi Inoue and 1 more

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Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diagnosis of multivessel coronary artery disease usingJapanese journal of radiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kentaro OharaDepartment of Radiology, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan.
Naoto KawaguchiDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan. n.kawa1113@gmail.com.
Hideki OkayamaDepartment of Cardiology, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan.
Hitomi UedaDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.
Ryutaro UenoDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.
Kuniaki HiraiDepartment of Radiology, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan.
Yuki TanabeDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.
Megumi MatsudaDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.
Tomoyuki KidoDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.
Takeshi InoueDepartment of Radiology, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan.
Teruhito KidoDepartment of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSplenic switch-off (SSO) is defined as a decrease in splenic radiotracer uptake following pharmacological stress. This study aimed to assess the clinical utility of SSO on adenosine triphosphate (ATP) MATERIALS AND

methodsWe analyzed 63 patients (mean age, 67 ± 11 years; 34 males) who underwent ATP

resultsNegative SSO was observed in 15 of 63 patients. Global MFR and global stress MBF were significantly higher in the positive SSO group than in the negative SSO group (2.4 ± 0.6 vs. 1.6 ± 0.6, P < 0.001, and 2.3 ± 0.5 vs. 1.5 ± 0.5 ml min

conclusionsThe presence of a splenic response based on the visual assessment of SSO may be used to identify an adequate pharmacological response. This can affect the diagnosis of CMD in patients with reduced MFR without CAD. This study showed the clinical utility of splenic switch-off in adenosine triphosphate

Indexed as

Adenosine TriphosphateAmmoniaNitrogen RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsSpleenAgedClinical RelevanceCoronary AngiographyCoronary Artery DiseaseCoronary CirculationFemaleHumansMaleMiddle AgedRetrospective StudiesAdenosine TriphosphateAmmoniaNitrogen-13Nitrogen RadioisotopesRadiopharmaceuticals13N-ammonia PETCoronary microvascular dysfunctionMyocardial flow reserveSplenic switch-off

Identifiers

PMID40156740
PMCPMC12204888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.