Evidence map›Paper›PMID 40156721›Full record

ArticleBrain topography2025

Spectral and Microstate EEG Analysis in Narcolepsy Type 1 and Type 2 Across Sleep Stages.

Shengpeng Liang, Yihong Cheng, Shixu Du, Dhirendra Paudel, Yan Xu, Bin Zhang

Abstract read
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In one paragraph

Article in Brain topography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shengpeng LiangDepartment of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, China.
Yihong ChengDepartment of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, China.
Shixu DuDepartment of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, China.
Dhirendra PaudelDepartment of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, China.
Yan XuDepartment of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, China.
Bin ZhangDepartment of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, China. zhang73bin@hotmail.com.

Funding

Foundation for Innovative Research Groups of the National Natural Science Foundation of China 82071488Nanfang Hospital Clinical Research Project of Southern Medical University 2021CR009National Key Research and Development Program of China 2021YFC2501500National Natural Science Foundation of China 82271525
6 · The paper itself

Abstract

backgroundThe primary distinction between narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) is the presence or absence of cataplexy, which is commonly determined through clinical interviews, though it can be prone to error due to vague patients descriptions.

objectiveThis study aimed to investigate EEG microstate differences between NT1 and NT2 and their correlation with clinical assessments.

methodsPolysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were performed on 14 NT1 and 13 NT2 patients from three hospitals, with data from the ISRUC-SLEEP dataset serving as the comparison group. After EEG preprocessing, we performed the spectral analysis in NT1 and NT2, followed by microstate analysis. Grand mean maps were used for backfitting to obtain microstate parameters. Then, Spearman correlation was performed between the microstate parameters and the ESS and MSLT parameters.

resultsWe found that the relative delta power in N2 was lower in the NT1 group compared to the NT2 group. Four microstates were clustered in all groups, and no statistical differences were observed in the microstate parameters between NT1 and NT2 groups. In the NT1 group, microstate D during wakefulness showed a positive correlation with ESS, while in the NT2 group, microstate D during wakefulness showed a negative correlation with ESS.

conclusionsThere are spectral differences between the NT1 and NT2 groups, and the opposite correlation between microstate D and ESS during wakefulness in NT1 and NT2 suggest that the underlying mechanisms leading to excessive daytime sleepiness in the two groups may be different.

Indexed as

BrainElectroencephalographyNarcolepsySleep StagesAdultFemaleHumansMaleMiddle AgedPolysomnographyYoung AdultEEG microstatesEpworth sleepiness scaleMultiple sleep latency testNarcolepsyPolysomnographySpectral analysis

Identifiers

PMID40156721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.