Trial reportInternational urology and nephrology2025
Endoscopic combined intrarenal surgery versus prone percutaneous nephrolithotomy for complex renal stones: critical assessment of a randomized trial.
Trial report in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis of Endoscopic Combined Intrarenal Surgery (ECIRS) versus Percutaneous Nephrolithotomy (PCNL) for Upper Urinary Tract Calculi.European urology open science · 2026Review
- Use of Novel 6.3 Fr Ureteroscope in Endoscopic Combined Intrarenal Surgery (ECIRS): Comparative Experience with Conventional Ureteroscopes.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy and safety of endoscopic combined intrarenal surgery (ECIRS) in the Galdakao-Modified Supine Valdivia (GMSV) position versus percutaneous nephrolithotomy (PCNL) in the prone position for managing complex kidney stones.
methodsThis prospective, randomized study was conducted in the urology departments of Benha University Hospital and Theodor Bilharz Research Institute between June 2021 and May 2024. A total of 60 patients with complex renal stones were randomly assigned to two groups (30 patients each). Group A underwent conventional percutaneous nephrolithotomy (PCNL) in the prone position, while Group B underwent endoscopic combined intrarenal surgery (ECIRS) in the Galdakao-Modified Supine Valdivia (GMSV) position. Data on demographic characteristics, clinical outcomes, perioperative parameters, and stone-free rates (SFR) were collected.
resultsNo significant differences were found between the two groups regarding preoperative demographic data and stone characteristics. However, operative time was significantly longer in the PCNL group (119 ± 18 min) compared to the ECIRS group (105 ± 14 min) (P = 0.002). The number of punctures was also significantly higher in the PCNL group than in the ECIRS group (P = 0.001). Immediate success was notably higher in the ECIRS group (83.3%) compared to the PCNL group (53.3%) (P = 0.012). However, no significant difference was observed between the groups concerning eventual success (P = 1.0).
conclusionECIRS is a highly effective treatment for complex renal stones, delivering favorable outcomes such as higher single-step stone-free rates, a lower incidence of adverse events, and a reduced need for auxiliary procedures.
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