Evidence map›Paper›PMID 40156631›Full record

ArticleClinical and experimental medicine2025

Undifferentiated connective tissue disease: the diagnoses critically revised-experience of a single center.

Ilaria Cavazzana, Paolo Semeraro, Cesare Tomasi, Elena Sofia Kessler, Silvia Piantoni, Alessia Caproli, Micaela Fredi, Franco Franceschini

Abstract read
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Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilaria CavazzanaRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, ERN-Reconnect Centre, ASST Spedali Civili, University of Brescia, Brescia, Italy. ilaria.cavazzana@unibs.it.ORCID http://orcid.org/0000-0002-2757-7120
Paolo SemeraroRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, ERN-Reconnect Centre, ASST Spedali Civili, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-7053-3086
Cesare TomasiRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, ERN-Reconnect Centre, ASST Spedali Civili, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-3699-8744
Elena Sofia KesslerRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, University of Brescia, Brescia, Italy.
Silvia PiantoniRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, ERN-Reconnect Centre, ASST Spedali Civili, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0003-0913-0197
Alessia CaproliRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-8933-7683
Micaela FrediRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, ERN-Reconnect Centre, ASST Spedali Civili, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0002-6511-4936
Franco FranceschiniRheumatology and Clinical Immunology Unit and Chair, Department of Experimental and Clinical Science, ERN-Reconnect Centre, ASST Spedali Civili, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0003-3678-6124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although anti-nuclear antibodies (ANA) are considered the main entry criteria for a diagnosis of undifferentiated connective tissue disease (UCTD), many patients show different rate of ANA positivity and questionable diagnoses. Aim of the study was to revise the UCTD diagnoses and analyse the main predictors of evolution in a monocentric cohort. We retrospectively revised the diagnoses of 331 ANA positive patients, with at least one year of follow-up, classified as UCTD from 2009 and 2017. The diagnosis of UCTD was confirmed in 180 cases (54.4%). The evolution occurred in 18% of cases, after a follow-up of 6.9 (SD: 4.4) years. Raynaud's phenomenon (RP) (OR: 2.39), puffy hands (OR: 6.3), anti-ENA (OR: 2.34), anti-Topoisomerase I antibodies (OR: 4.93), rheumatoid factor (RF) (OR: 2.86) were associated with evolution. Evolution in Systemic Lupus Erythematosus (SLE) occurred in 5 patients (2.78%) and associated with the addition of new autoantibodies, compared with other evolutions (p: 0.034; OR: 12; 95CI: 1.4-103.4). Evolution in Systemic Sclerosis and pSS was found in 14 (7.8%) and 8 cases (4.4%), respectively. Puffy hands and RF positivity as the predictors of SSc and pSS evolution, respectively. A confirmed diagnosis of UCTD, according with the available criteria, was assessed in about a half patients. The occurrence of puffy hands since the onset defines a patient with a potential evolution into SSc, while the addition of new specific autoantibodies represents a typical "fingerprint" of patients developing SLE. Trial registration: Studio ANACTD np 1318.

Indexed as

Antibodies, AntinuclearConnective Tissue DiseasesUndifferentiated Connective Tissue DiseasesAdultAgedAutoantibodiesFemaleHumansLupus Erythematosus, SystemicMaleMiddle AgedRaynaud DiseaseRetrospective StudiesRheumatoid FactorYoung AdultAntibodies, AntinuclearAutoantibodiesRheumatoid FactorAnti-nuclear antibodiesRaynaud’s phenomenonSystemic lupus erythematosusSystemic sclerosisUndifferentiated connective tissue disease

Identifiers

PMID40156631
PMCPMC11954846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.