Evidence map›Paper›PMID 40156581›Full record

ArticleCirculation. Cardiovascular quality and outcomes2025

Validation of Medicare Advantage Claims for Long-Term Outcome Assessment in Low-Risk Aortic Valve Replacement.

Christina Lalani, Frank Medina, Andrew S Oseran, Lichen Liang, Yang Song, Neel M Butala, Dhruv S Kazi, David J Cohen, Jordan B Strom, Rishi K Wadhera and 1 more

Abstract readValidation StudyComparative Study
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina LalaniDivision of Cardiology (C.L., A.S.O., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0009-0003-7340-8111
Frank MedinaRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology (C.L., F.M., A.S.O., L.L., Y.S., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0009-0005-1992-5892
Andrew S OseranDivision of Cardiology (C.L., A.S.O., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Lichen LiangRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology (C.L., F.M., A.S.O., L.L., Y.S., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Yang SongRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology (C.L., F.M., A.S.O., L.L., Y.S., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-8052-8395
Neel M ButalaDivision of Cardiology, Rocky Mountain Regional VA Medical Center, University of Colorado School of Medicine, Aurora (N.B.).ORCID 0000-0001-6937-4041
Dhruv S KaziDivision of Cardiology (C.L., A.S.O., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-9510-2979
David J CohenCardiovascular Research Foundation, New York, NY (D.J.C.).ORCID 0000-0001-9163-724X
Jordan B StromDivision of Cardiology (C.L., A.S.O., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-6592-6141
Rishi K WadheraDivision of Cardiology (C.L., A.S.O., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0003-1089-3896
Robert W YehDivision of Cardiology (C.L., A.S.O., D.S.K., J.B.S., R.K.W., R.W.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-0564-4468

Funding

Use of Registries, Claims and Health System Data to Enhance the Evaluation of Cardiovascular Therapies in Clinical TrialsR01HL136708 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Issa J. Dahabreh, Robert Yeh · 2017 to 2026
$6.9M
Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)R01HL169517 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Jordan Blair Strom · 2023 to 2026
$3.1M
A Novel Approach to Examine Within-Class Therapeutic Exchangeability of MedicationsR01AG063937 · NIA · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI GERHARD, TOBIAS · 2020 to 2024
$2.9M
Training Program in Cardiovascular ResearchT32HL160522 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Jennifer E Ho · 2022 to 2026
$2.7M
Cardiac Ultrasound Radiomics-Guided Deep Neural Networks for Acute Myocardial Infarction Precision PhenotypingR01HL173998 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Partho P Sengupta · 2025 to 2026
$1.2M
Using Claims-Based Signatures of Frailty to Support Individualized Treatment of Aortic Valve Stenosis and Coronary Artery DiseaseK24HL150321 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Robert Yeh · 2020 to 2026
$862k
NHLBI NIH HHS K24 HL150321NHLBI NIH HHS R01 HL136708NHLBI NIH HHS R01 HL169517NHLBI NIH HHS R01 HL173998NHLBI NIH HHS T32 HL160522NIA NIH HHS R01 AG063937
6 · The paper itself

Abstract

backgroundAlthough Medicare Advantage (MA) plans provide coverage to >50% of Medicare beneficiaries, it is unclear whether MA claims can be used similarly to Medicare Fee-For-Service (FFS) claims for clinical outcomes assessment. In this study, we evaluate the accuracy of claims algorithms previously validated in FFS to assess comorbidities and outcomes in MA patients after aortic valve replacement.

methodsWe compared the concordance of 11 claims-based covariates (diabetes, hypertension, atrial flutter/fibrillation, myocardial infarction) and outcomes (stroke, disabling stroke, transient ischemic attack, major vascular complication, bleeding, permanent pacemaker implantation, death) among FFS and MA patients with the covariates and adjudicated outcomes in the multinational Evolut Low-Risk Trial (2016-2018). We used claims algorithms for 1-year outcomes and calculated sensitivity, specificity, positive predictive value, negative predictive value, and kappa, using adjudicated outcomes as the reference. We compared the kappa for MA versus FFS using the 2-sample

resultsAmong 1139 US patients aged 65+ years old in the Evolut Low-Risk Trial, 782 patients (175 MA and 607 FFS) were linked to claims data and had complete comorbidity data. Among all covariates, claims algorithms for covariates had sensitivities ≥85% for identifying diabetes, atrial flutter/fibrillation, and hypertension in MA and FFS. For the outcomes, sensitivities were ≥85% for bleeding (comprehensive), permanent pacemaker implantation, and death. The kappa was higher in MA versus FFS for diabetes (

conclusionsMedicare claims have a similar level of kappa agreement in MA versus FFS for most covariates and outcomes. As patients shift to MA, ascertainment of outcomes using Medicare claims in postapproval studies remains valid for select outcomes.

Indexed as

Administrative Claims, HealthcareAortic ValveFee-for-Service PlansHeart Valve Prosthesis ImplantationInsurance Claim ReviewMedicare Part CAgedAged, 80 and overAlgorithmsComorbidityFemaleHumansMalePredictive Value of TestsReproducibility of ResultsRisk Assessmentaortic valveMedicare Part Cstroke

Identifiers

PMID40156581
PMCPMC12092182

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.