ArticleAsian Pacific journal of cancer prevention : APJCP2025
Development and Characterization of Curcumin Loaded PEGylated Niosomal Nanoparticles: Potential Anti-Cancer Effect on Breast Cancer Cells through RFC Gene Expression.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Telomeres, Telomerase, and Curcumin: A New Frontier in Cancer Therapy: A Narrative Review.Biomedicines · 2025Review
- Targeting the redox-programmed cell death axis in breast cancer: from molecular mechanisms to therapeutic resistance.Cell death discovery · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer is the second leading cause of cancer deaths among women. Recent studies emphasize the significant role of folate metabolic pathways in cancer progression. The Reduced Folate Carrier (RFC), a folate transporter in cell membranes, plays an essential role in transporting folate receptor-dependent drugs. Curcumin, a bioactive compound with anticancer and anti-inflammatory effects, is hindered by low stability and a short half-life. Niosomes are versatile nanoparticles that can deliver both hydrophilic and hydrophobic drugs.
objectiveThis study aims to evaluate the anticancer effects of curcumin-loaded niosomal nanoparticles, focusing on their impact on RFC, BAX, and BCL-2 gene expression in MDA-MB-231 breast cancer cells.
methodsCurcumin-loaded noisomal nanoparticles were synthesized by the thin-film hydration method. Then, the morphology, size, and physico-chemical nanoparticles were determined by FE-SEM, DLS, and FT-IR methods, respectively. The MTT results determined the cytotoxicity of free and nano-formulated curcumin; also, the gene expression of RFC, BCL-2, and BAX was evaluated using the Real-Time PCR method. Furthermore, apoptosis and cell cycle analysis were investigated by Flow cytometry. Results: The results of the physicochemical characteristics of the nanoparticles showed that curcumin was appropriately loaded in niosomal NPs. The MTT results showed that curcumin loaded in niosomal NPs has a higher anti-proliferative effect than free curcumin. Real-time PCR results showed increased RFC and BAX gene expression and decreased BCL-2 gene expression; this change was more significant in the treatment with nano-formulated curcumin. The apoptosis and cell cycle analysis also confirmed that free and nano-formulated curcumin induces apoptosis and cell cycle arrest. Conclusion: Overall, the results suggested that curcumin loaded in niosomal nanoparticles effectively improves the anticancer effect and could be a capable approach for treating breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.