Evidence map›Paper›PMID 40156369›Full record

Observational studyThe Laryngoscope2025

Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis.

Christine M Liu, Jakob L Fischer, Michelle J Lee, Jess C Mace, Adam J Kimple, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Sei Y Chung and 24 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04469439 (The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04469439 recruitingnot on this map

The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy

TypeobservationalSponsorUniversity of California, Los AngelesRan2020 to 2027Enrolled170ConditionsChronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Christine M LiuDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-9985-4775
Jakob L FischerDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-8896-671X
Michelle J LeeDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.
Jess C MaceDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, Oregon, USA.
Adam J KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Karolin MarkarianCTSI, David Geffen School of Medicine University of California, Los Angeles, Los Angeles, California, USA.
Jeremiah A AltDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0560-5028
Todd E BodnerDepartment of Psychology, Portland State University, Portland, Oregon, USA.
Naweed I ChowdhuryDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt Health, Nashville, Tennessee, USA.
Sei Y ChungDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Patricia H EshaghianDepartment of Pulmonary Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Yuqing A GaoDepartment of Pulmonary Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Anne E GetzDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alta, California, USA.ORCID 0000-0002-0786-4675
Ashoke KhanwalkarDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
Jivianne T LeeDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-0711-855X
Douglas A LiDepartment of Pulmonary Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Meghan NorrisDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alta, California, USA.ORCID 0000-0003-4454-0861
Jonathan B OverdevestDepartment of Otolaryngology-Head and Neck Surgery, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-1152-2512
Cameran OwensDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
Zara M PatelDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alta, California, USA.ORCID 0000-0003-2072-982X
Lindsay E PappasDepartment of Pulmonary Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Katie PochDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Kristine A SmithDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Timothy L SmithDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, Oregon, USA.ORCID 0000-0002-6424-7083
Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-4304-595X
Jeffrey D SuhDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.
Grant A TurnerDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, Oregon, USA.
Marilene B WangDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-2799-6325
Jennifer L Taylor-CousarDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Milene T SaavedraDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Daniel M BeswickDepartment of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1898-0417

Funding

Enabling careers as surgeon-scientists in otolaryngology-head and neck surgeryR25DC020151 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer L Long · 2022 to 2026
$887k
Cystic Fibrosis Foundation BESWIC20A0Cystic Fibrosis Foundation BESWICK22Y5NIDCD NIH HHS R25 DC020151NIDCD NIH HHS R25DC020151
6 · The paper itself

Abstract

objectivesOlfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF) and chronic rhinosinusitis (CRS). OD is associated with impaired quality of life (QOL) and dietary alterations in certain non-CF populations. This study explored relationships between OD, QOL, and modulator use in PwCF.

methodsThis is a cross-sectional analysis of an ongoing multicenter, prospective study (2019-2023) investigating PwCF with comorbid CRS. Participants completed the 40-Question Smell Identification Test (SIT-40), 22-question SinoNasal Outcome Test-(SNOT-22), Questionnaire of Olfactory Disorders (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R). Clinical and sinus CT data were collected. After stratification by SIT-40 score, data was analyzed by chi-square, Kruskal-Wallis, Spearman correlation, and logistic regression to identify factors associated with OD.

resultsOf 59 participants, those with anosmia (n = 12) had worse eating-related QOL (CFQ-R eating) compared to individuals with normosmia (n = 16) and hyposmia (n = 31). Participants with anosmia had worse sinus CT scores than those with hyposmia. Although PwCF treated with highly effective modulator therapy (HEMT; n = 30) had better CT scores vs. non-HEMT individuals (n = 23), rates of OD in both groups were comparable. Higher SNOT-22 total scores were associated with increased odds of hyposmia or anosmia. In an eating-related QOD-NS subscore, those with worse CFQ-R eating had 2.38 times higher odds of having OD. Each point decrease in CFQ-R eating domain score was associated with 10% increased odds of OD.

conclusionIn PwCF, OD was associated with increased CRS severity, impaired olfactory QOL, and decreased CFQ-R eating. There were no differences in SIT-40 or QOD-NS scores based on HEMT status. LEVEL OF EVIDENCE: 3:

trial registrationNCT04469439.

Indexed as

Cystic FibrosisFood PreferencesOlfaction DisordersQuality of LifeRhinitisSinusitisSmellAdultChronic DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective StudiesRhinosinusitisCFTR modulator therapychronic rhinosinusitiscystic fibrosiselexacaftor/tezacaftor/ivacaftorolfactory dysfunction

Identifiers

PMID40156369
PMCPMC12230906

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.