Evidence map›Paper›PMID 40156204›Full record

ReviewCancer medicine2025

Dose-Volume Constraints for Thoracic, Abdominal, and Pelvic Carbon Ion Radiotherapy: A Literature Review.

Maria Varnava, Mutsumi Tashiro, Masahiko Okamoto, Ken Ando, Nobutero Kubo, Hidemasa Kawamura, Masahiro Onishi, Kei Shibuya, Takuya Kumazawa, Takeru Ohtaka and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria VarnavaGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.ORCID https://orcid.org/0000-0001-7408-2975
Mutsumi TashiroGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.ORCID https://orcid.org/0000-0003-3253-0527
Masahiko OkamotoGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Ken AndoGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Nobutero KuboGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Hidemasa KawamuraGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.ORCID https://orcid.org/0000-0003-4899-1715
Masahiro OnishiGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Kei ShibuyaGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Takuya KumazawaGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Takeru OhtakaGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Tatsuya OhnoGunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApplying dose-volume constraints is extremely important in ensuring the safe use of radiotherapy. However, constraints for carbon ion radiotherapy (CIRT) have not been established yet. This review aims to summarize dose-volume constraints for thoracic, abdominal, and pelvic CIRT that have been identified through previous research based on the Japanese models for relative biological effectiveness (RBE).

resultsConstraints are reported for the lungs, liver, stomach, gastrointestinal tract, rectum, sigmoid, bladder, nerves, rib, femoral head, sacrum, and skin. The constraints are classified into hard and soft to aid in determining whether priority should be given to the target coverage or organ-at-risk (OAR) sparing during treatment planning.

conclusionsFurther research is necessary to verify the applicability of the reported constraints and to identify constraints for the OARs that have not been investigated yet.

Indexed as

Heavy Ion RadiotherapyThoracic NeoplasmsHumansOrgans at RiskPelvisRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRelative Biological Effectivenessabdominal cancercarbon ion radiotherapydose–volume constraintsorgans at riskpelvic cancerthoracic cancer

Identifiers

PMID40156204
PMCPMC11953175

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.