Evidence map›Paper›PMID 40156139›Full record

ArticleThe British journal of radiology2025

Simultaneous ultra-high resolution multi-energy cardiac imaging in a dual-source photon counting detector CT system.

Elisabeth Shanblatt, Kishore Rajendran, Joseph R Swicklik, Thomas Allmendinger, Bernhard Schmidt, Thomas Flohr, Cynthia H McCollough, Shuai Leng

Abstract read
In one paragraph

Article in The British journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Trading off Iodine and Radiation Dose in Coronary Computed Tomography.Journal of cardiovascular development and disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elisabeth ShanblattSiemens Medical Solutions USA, Inc, Malvern, PA 19355, United States.
Kishore RajendranDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.
Joseph R SwicklikDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.
Thomas AllmendingerSiemens Healthineers, Forchheim, 91301, Germany.
Bernhard SchmidtSiemens Healthineers, Forchheim, 91301, Germany.
Thomas FlohrInstitute of Radiology, Friedrich-Alexander University, Erlangen, 91054, Germany.
Cynthia H McColloughDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0002-5346-332X
Shuai LengDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0002-6453-9481

Funding

Comprehensive characterization of coronary atherosclerotic disease using photon-counting-detector dual-source CT and its impact on patient managementR01EB028590 · NIBIB · MAYO CLINIC ROCHESTER · PI LENG, SHUAI, MCCOLLOUGH, CYNTHIA H · 2020 to 2023
$2.6M
NIBIB NIH HHS R01 EB028590NIH HHS R01EB028590
6 · The paper itself

Abstract

objectivesTo assess quantitative and qualitative image characteristics in phantoms and patients using a simultaneous ultra-high resolution (UHR) and multi-energy (ME) dual-source cardiac scan mode in a photon counting detector (PCD) CT scanner.

methodsUHR-ME cardiac scans were performed to determine the spatial resolution and multi-energy performance. UHR reconstructions were completed to measure transverse and axial spatial resolution in terms of modulation transfer function (MTF) and slice sensitivity profile (SSP). Virtual monoenergetic images (VMIs), virtual non-contrast (VNC) images, and iodine concentration images were created using moderately sharp reconstruction kernels to assess ME performance. With IRB approval, coronary CT angiograms were acquired in 19 patients using the UHR-ME mode, from which iodine contrast-to-noise ratio (CNR) was measured. Various ME post-processing tasks were performed to show the utility of the spectral capabilities.

resultsVMIs showed a mean CT number error of 6.0%, while iodine accuracy was 0.71 mg/cc (root-mean-square-error). Spatial resolution matched well with a standard UHR mode. Patient images showed a trend of higher CNR at lower keV, while higher keV images showed decreased calcium blooming. ME techniques to separate iodine and calcium were used successfully.

conclusionsThe combination of UHR-ME cardiac mode retains UHR image quality while providing flexibility for ME post-processing. ADVANCES IN KNOWLEDGE: Cardiac UHR-ME PCD-CT scanning offers simultaneous UHR and ME imaging without loss of spatial or temporal resolution or quantitative accuracy.

Indexed as

Computed Tomography AngiographyCoronary AngiographyHeartRadiography, Dual-Energy Scanned ProjectionTomography, X-Ray ComputedAgedFemaleHumansMaleMiddle AgedPhantoms, ImagingPhotonsRadiographic Image Interpretation, Computer-AssistedSignal-To-Noise Ratiocardiac CTmulti-energy imagingphoton countingultra-high-spatial resolution

Identifiers

PMID40156139
PMCPMC12486180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.