Evidence map›Paper›PMID 40156095›Full record

ArticlePhysiological reports2025

Changes in kidney functions following acute infusion of low molecular weight polyvinylpyrrolidone in male rats.

Qi Yan, Qingshang Yan, Henry Shen, Tong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qi YanDepartment of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut, USA.
Qingshang YanDepartment of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut, USA.
Henry ShenDepartment of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut, USA.
Tong WangDepartment of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-7054-2540

Funding

The Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J. · 1986 to 2018
$29.5M
Defective flow-dependent tubule transport in the pathogenesis of kidney diseaseR01DK117650 · NIDDK · YALE UNIVERSITY · PI WANG, TONG WANG · 2019 to 2022
$1.5M
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) PO1 DK 17433NIDDK NIH HHS P01 DK017433NIDDK NIH HHS R01 DK117650
6 · The paper itself

Abstract

Polyvinylpyrrolidone (PVP), a water-soluble homopolymer, has been widely used in food, beverage, medical, and experimental tissue preparations. However, the effect of PVP on renal functions remains unknown. We investigated the acute administration of low MW of PVP on renal functions and whether it produces a toxic effect on the kidney. Renal clearance experiments were performed in rats and showed PVP infusion elicited significant diuretic and natriuretic effects. Urine volume, absolute (ENa), and fractional (FENa) Na

Indexed as

DiureticsKidneyPovidoneAlpha-GlobulinsAnimalsMaleMolecular WeightNatriuresisRatsRats, Sprague-DawleyRats, WistarSodiumalpha-1-microglobulinAlpha-GlobulinsDiureticsPovidoneSodiumNa+ and K+ absorptionPVP infusionrenal clearance

Identifiers

PMID40156095
PMCPMC11953058

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.