Evidence map›Paper›PMID 40156058›Full record

ReviewJournal of anesthesia, analgesia and critical care2025

A narrative review of glucagon-like peptide-1 receptor agonists prior to deep sedation or general anesthesia.

Luigi Vetrugno, Cristian Deana, Andrea Da Porto, Enrico Boero, Valentina Bellini, Daniele Guerino Biasucci, Elena Giovanna Bignami

Abstract readReview
In one paragraph

Review in Journal of anesthesia, analgesia and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luigi VetrugnoDepartment of Emergency, Health Integrated Agency of Friuli Centrale, Tolmezzo, Italy. luigi.vetrugno@unich.it.
Cristian DeanaDepartment of Anesthesia and Intensive Care, Health Integrated Agency of Friuli Centrale, Udine, Italy.
Andrea Da PortoDiabetes and Metabolism Unit, Department of Internal Medicine, Health Integrated Agency of Friuli Centrale, Udine, Italy.
Enrico BoeroAnesthesia and Intensive Care Unit, San Giovanni Bosco Hospital, Turin, Italy.
Valentina BelliniCritical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Daniele Guerino BiasucciDepartment of Clinical Science and Translational Medicine, Tor Vergata' University of Rome, Rome, Italy.
Elena Giovanna BignamiCritical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-1 receptor agonists are a class of drugs that mimic a natural incretin hormone released by the intestine after meals, and they are well-suited for treating type 2 diabetes. Glucagon-like peptide-1 receptor agonists also lead to satiety and appetite reduction through action on the brain's appetite regulation centers, leading to weight loss in obese patients. However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period. The purpose of this review is (i) to explore the present knowledge about the risk of aspiration before anesthesia; (ii) to describe the method for evaluating the presence of liquid and food in the stomach before surgery; and (iii) to balance the actual warning with the opportunity for future discovery about their benefits.

Indexed as

AnesthesiaFastingGLP-1 receptor agonistsPerioperative periodUltrasound

Identifiers

PMID40156058
PMCPMC11951578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.