ArticleBMC pregnancy and childbirth2025
Hormonal and metabolic influences on outcomes in PCOS undergoing assisted reproduction: the role of BMI in fresh embryo transfers.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combined liraglutide and metformin therapy in overweight or obese women with polycystic ovary syndrome: A systematic review and meta-analysis.Diabetes, obesity & metabolism · 2025 · on this mapPooled it
- Effect of Probiotic Supplementation on Reproductive Outcomes of Women With Polycystic Ovary Syndrome Who Are Candidates for Intrauterine Insemination: A Randomized, Double-Blind, Placebo-Controlled Trial.Endocrinology, diabetes & metabolism · 2026Trial
- Exploring Co-Occurring Clinical and Treatment Characteristics Associated with In Vitro Fertilization Failure in Polycystic Ovary Syndrome: An Association Rule Mining Approach.Healthcare (Basel, Switzerland) · 2026Article
- A nomogram to predict early spontaneous abortion in women with polycystic ovary syndrome: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Impact of retrieved oocyte number on IVF outcomes in polycystic ovary syndrome: a retrospective cohort study.Journal of endocrinological investigation · 2026Article
- BMI-stratified phenotypes of polycystic ovary syndrome: advances in gut microbiota research and personalized management strategies.Frontiers in endocrinology · 2026Review
- Clinical factors associated with recurrent pregnancy loss status in women with polyendocrine metabolic ovarian syndrome.Frontiers in endocrinology · 2026Article
- Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Association of paternal age with embryological outcomes and β-hCG positivity in women with polycystic ovary syndrome undergoing ICSI: a retrospective cohort study.Frontiers in medicine · 2026Article
- Effect of Xiaonang Yusi decoction () on IVF outcomes in patients with phlegm-dampness type PCOS: a prospective cohort study with supporting metabolomics, network pharmacology, and molecular docking analysis.Frontiers in medicine · 2026Article
- Article
- Long-Term Reproductive Outcomes After Palmer-Type Neosalpingostomy in Hydrosalpinx: A Seven-Year Real-World Cohort Study.Journal of clinical medicine · 2025Article
- Independent Elevation of Leptin and Reduction of Protective Adipokines in Polycystic Ovary Syndrome: A BMI-Matched Case-Control Study.International journal of women's health · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThis retrospective study aimed to examine the influence of hormonal and metabolic parameters across varying body mass index (BMI) levels on embryo quality and pregnancy outcomes in fresh embryo transfer cycles using assisted reproductive technology (ART) in patients diagnosed with polycystic ovary syndrome (PCOS).
methodsA total of 167 women diagnosed with PCOS and 266 women without PCOS (control group) were included. Metabolic and hormonal parameters was compared between the two groups to evaluate their relationship with embryo quality and pregnancy outcomes. Subgroup analyses were performed to assess these effects in patients with normal and high BMI.
resultsIn the PCOS group, hormonal and metabolic parameters such as insulin, blood lipids, luteinizing hormone (LH), anti-Müllerian hormone (AMH) and antral follicle counting (AFC) were significantly higher than in the control group. The PCOS group also produced more blastocysts and a higher proportion of high-quality blastocysts. However, pregnancy rate and clinical pregnancy rates were similar between the two groups, regardless of BMI. Among the high-BMI PCOS patients, the miscarriage rate was significantly higher compared to the control group, and its rate showed a positive correlation with BMI, LH, and total testosterone (TSTO) levels.
conclusionHormonal imbalances and glucose-lipid metabolism have minimal influence on embryo development in PCOS patients. However, hormonal factors-particularly in PCOS patients with high BMI-significantly influence pregnancy outcomes, with elevated BMI and androgen levels increasing the risk of miscarriage. These findings underscore the importance of addressing metabolic and hormonal factors in the management of PCOS patients undergoing ART.
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