Evidence map›Paper›PMID 40155938›Full record

ArticleBMC pediatrics2025

Hemodynamic profile of cerebral arteries using transcranial Doppler in children with sickle cell disease compared to children without sickle cell disease: Prospective analytical study.

Patrick Landu Kinkunda, Aliocha Natuhoyila Nkodila, Joël Kashale Mutamba, Orlin Mamona Yindula, Roger Izeidi Gangale, Lilly Mokulayanga, Émeraude Manzombi, Djo Mbo-M Iyoto, Lys Makwanza, Cynthia Bukumba Minouche and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Patrick Landu KinkundaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Aliocha Natuhoyila NkodilaDepartment of Family Medicine and Primary Health Care, Protestant University of Congo, Kinshasa, Democratic Republic of Congo. nkodilaaliocha@gmail.com.
Joël Kashale MutambaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Orlin Mamona YindulaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Roger Izeidi GangaleDepartment of Radiology and Medical Imaging, Les Clinics du Coeur, Kinshasa, Democratic Republic of Congo.
Lilly MokulayangaDepartment of Radiology and Medical Imaging, Les Clinics du Coeur, Kinshasa, Democratic Republic of Congo.
Émeraude ManzombiAnemic SS" Hospital Center Saint Crispin, Kinshasa, Democratic Republic of Congo.
Djo Mbo-M IyotoDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Lys MakwanzaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Cynthia Bukumba MinoucheDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Stéphane Tongo YandaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Antoine Aundu MoluaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Jean Tshibola MukayaDepartment of Radiology and Medical Imaging, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral vasculopathy is a frequent and serious complication of major sickle cell disease syndromes. Transcerebral Doppler (TCD) can detect stenosis of the main arteries at the base of the skull before stroke occurs, and initiate therapy to avoid complications. The objective of the study is to evaluate and compare the hemodynamic profile of the middle cerebral artery using TCD in children with sickle cell disease compared to children without sickle cell disease.

methodProspective analytical study extended over a 6-month period from July 04, 2023 to December 28, 2023. The study population consisted of subjects followed for homozygous sickle cell disease SS and non-sickle cell subjects received at the above-mentioned centers, of all sexes, aged 2 to 16 years at most.

resultsWe recruited 182 children (52.2% male and 47.8% female) divided into 70 children with sickle cell disease and 112 children without sickle cell disease. The mean of Maximum systolic velocity (MSV) on the left was 85.0 ± 49.5 cm/s in sickle cell patients and 84.5 ± 17.8 cm/s in non-sickle cell patients. The mean of telediastolic velocity (TDV) was 40.9 ± 31.2 cm/s in sickle cell patients and 44.0 ± 15.8 cm/s in non-sickle cell patients. The mean maximum velocity (MMV) was 53.22 ± 39.0 cm/s in sickle cell patients and 57.5 ± 16.3 cm/s in non-sickle cell patients.

conclusionThe mean velocity of children with sickle cell disease was lower than that of non-sickle cell patients, and the peak systolic velocity of children with sickle cell disease was slightly higher than those of children without sickle cell disease.

Indexed as

Anemia, Sickle CellHemodynamicsMiddle Cerebral ArteryUltrasonography, Doppler, TranscranialAdolescentBlood Flow VelocityCase-Control StudiesChildChild, PreschoolFemaleHumansMaleProspective StudiesCerebral vasculopathyChildSickle cell diseaseStrokeTranscranial Doppler

Identifiers

PMID40155938
PMCPMC11951702

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