Evidence map›Paper›PMID 40155911›Full record

ArticleBMC surgery2025

An innovative animal experimental model of rib fracture with bone displacement.

Chien-An Liao, Shih-Ching Kang, Tai-Horng Young, Chien-Hung Liao, Chi-Hsun Hsieh, Yi-Teng Fong, Chun-Chieh Chuang, Chih-Hao Chen

Abstract read
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Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chien-An LiaoDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Shih-Ching KangDepartment of Trauma and Emergency Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Tai-Horng YoungDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Chien-Hung LiaoDepartment of Trauma and Emergency Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chi-Hsun HsiehDepartment of Trauma and Emergency Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yi-Teng FongDepartment of Trauma and Emergency Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chun-Chieh ChuangSchool of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
Chih-Hao ChenChang Gung University College of Medicine, Taoyuan, Taiwan. m8407@cgmh.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRib fractures, the most common blunt chest trauma worldwide, have been evaluated in multiple retrospective cohort studies. Histology laboratories using innovative techniques are crucial to improving patient outcomes; animal models are especially valuable in this regard. Currently, the creation of animal models of fractures involves cutting to avoid lethal pleural injury and induce linear fractures incompatible with real-world morphology. Suitable models with bone displacement, which are common surgical targets, are limited. Therefore, we aimed to develop an animal experimental model that aligns with real-world clinical conditions and allows for more in-depth research on blunt chest trauma.

methodsWe conducted an animal study using New Zealand rabbits to create fractures with displacement, without injuring the pleura. A facial bone drill was used to create several fracture holes in the ribs that were carefully dissected using a rongeur and scissors. After reaching the border between the bone and pleura, they were separated through blunt dissection with scissors. Fractures were created without injuring the pleura, and a rongeur was used to displace the bones.

resultsSeven rabbits successfully underwent surgery, with each awakening without pleural injury and pneumothorax. Surgery effectiveness was primarily assessed using chest computed tomography (CT) to evaluate types of rib fractures. CT was performed in the second week and second and third months postoperatively. All rabbits exhibited visibly displaced rib fractures, and no additional chest complications were observed.

conclusionsThis innovative animal model allowed us to study pathophysiological changes following rib fracture. Future studies investigating new medical materials and surgical procedures will benefit from this animal model.

Indexed as

Disease Models, AnimalRib FracturesAnimalsMaleRabbitsTomography, X-Ray ComputedWounds, NonpenetratingAnimal modelBone displacementFractureRabbitRib

Identifiers

PMID40155911
PMCPMC11951796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.