Evidence map›Paper›PMID 40155901›Full record

ArticleBMC public health2025

Chronic loneliness and longitudinal changes in cognitive functioning.

Jee Eun Kang, Lynn M Martire, Jennifer E Graham-Engeland, David E Almeida, Martin J Sliwinski

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jee Eun KangCenter for Healthy Aging, The Pennsylvania State University, Biobehavioral Health Building, University Park, PA, 16802, USA. jxk692@psu.edu.
Lynn M MartireCenter for Healthy Aging, The Pennsylvania State University, Biobehavioral Health Building, University Park, PA, 16802, USA.
Jennifer E Graham-EngelandCenter for Healthy Aging, The Pennsylvania State University, Biobehavioral Health Building, University Park, PA, 16802, USA.
David E AlmeidaCenter for Healthy Aging, The Pennsylvania State University, Biobehavioral Health Building, University Park, PA, 16802, USA.
Martin J SliwinskiCenter for Healthy Aging, The Pennsylvania State University, Biobehavioral Health Building, University Park, PA, 16802, USA.

Funding

Ambulatory Methods for Measuring Cognitive ChangeU2CAG060408 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SLIWINSKI, MARTIN J · 2018 to 2022
$14.9M
Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
Diverging Effects of Closeness in Older Adults with Chronic Low Back Pain and Spousal CaregiversR01AG063241 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI MARTIRE, LYNN M. · 2020 to 2024
$2.7M
Inflammatory Mediators of Stress and Cognitive AgingR01AG042595 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI ENGELAND, CHRISTOPHER G, GRAHAM-ENGELAND, JENNIFER ELISE · 2012 to 2016
$1.6M
National Institute on Aging of the National Institutes of Health U2CAG060408NIA NIH HHS R01 AG042595NIA NIH HHS R01 AG063241NIA NIH HHS T32 AG049676NIA NIH HHS U2C AG060408
6 · The paper itself

Abstract

backgroundLoneliness is a worldwide concern with significant health implications that may be a significant risk factor for Alzheimer's disease and related dementias. In light of the importance of detecting early cognitive changes and risk factors influencing cognitive health, this study examined whether chronic loneliness predicted cognitive changes among young and middle-aged adults.

methodsThis study utilizes data from a longitudinal measurement burst study spanning over two years, comprising three waves of data collection. A systematically recruited young to mid-life adult sample (25- 65 years) included 172 racially and economically diverse participants who provided information about loneliness for at least two consecutive waves. Chronic loneliness was defined based on the validated multi-item PROMIS Social Isolation scale. We assessed working memory, processing speed, and spatial memory in a measurement burst design using mobile cognitive assessments. Multilevel growth models were conducted to examine whether chronic loneliness was associated with changes in cognitive performance during the study period of up to two years.

resultsResults revealed that chronic loneliness was not associated with baseline performance of working memory, processing speed, spatial memory or global cognitive performance, but chronic loneliness was associated with differential cognitive trajectories, specifically a lack of retest related improvement. There were no significant changes in cognitive performance for the chronic loneliness group across waves, whereas significant improvements were observed in those who were not chronically lonely.

conclusionsThis study offers insights into the impact of chronic loneliness on cognitive changes in young and middle-aged adults, revealing that chronically lonely individuals did not exhibit the practice-related improvements that are commonly observed in longitudinal studies. Findings suggest the potential significance of identifying and addressing chronic loneliness promptly to prevent potential cognitive consequences of chronic loneliness.

Indexed as

CognitionLonelinessAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedChronic lonelinessCognitionEcological momentary assessmentMeasurement burst designMobile cognitive assessmentProcessing speedSpatial memoryWorking memory

Identifiers

PMID40155901
PMCPMC11954266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.