Evidence map›Paper›PMID 40155861›Full record

ArticleBMC cancer2025

Heterogeneity of T cells regulates tumor immunity mediated by Helicobacter pylori infection in gastric cancer.

Zhisheng Wu, Xinya Wang, Shujing Shi, Deyuan Kong, Chuanli Ren, Lijun Bian, Yuanliang Gu, Fangmei An, Qiang Zhan, Caiwang Yan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Advances inOncology letters · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhisheng Wu *School of Chemistry and Chemical Engineering, Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Medical School, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China.
Xinya Wang *Wuxi People's Hospital, Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Wuxi, China.
Shujing Shi *Department of Rehabilitation, School of Sport and Health, Nanjing Sport Institute, Nanjing, China.
Deyuan Kong *Department of Immunology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China.
Chuanli RenDepartment of Laboratory Medicine, Clinical Medical College of Yangzhou University, Yangzhou, China.
Lijun BianDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Yuanliang GuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Fangmei AnWuxi People's Hospital, Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Wuxi, China.
Qiang ZhanWuxi People's Hospital, Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Wuxi, China.
Caiwang YanWuxi People's Hospital, Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Wuxi, China.
Chupeng HuDepartment of Immunology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China. hcpzzq15651677721@126.com.
Yun ChenSchool of Chemistry and Chemical Engineering, Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Medical School, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China. chenyun@njmu.edu.cn.
Runqiu JiangJiangsu Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China. jiangrq@nju.edu.cn.
Jinfei ChenDepartment of Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. jinfeichen@sohu.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of Helicobacter pylori (H. pylori) status on gastric cancer survival remains unclear. In this study, we conducted a prognostic analysis of 488 gastric cancer patients and performed single-cell RNA sequencing (scRNA-seq) on 18,717 T cells from six tumor samples with varying H. pylori statuses. Our findings revealed that gastric cancer patients with H. pylori infection had significantly longer survival times compared to those with negative H. pylori status. After unsupervised re-clustering of T cells based on scRNA-seq data, we identified ten CD4

Indexed as

CD8-Positive T-LymphocytesHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsAgedCD4-Positive T-LymphocytesFemaleHumansMaleMiddle AgedPrognosisRNA-SeqSingle-Cell AnalysisGastric cancerHelicobacter pyloriImmune microenvironmentSurvival

Identifiers

PMID40155861
PMCPMC11954285

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.