Evidence map›Paper›PMID 40155813›Full record

ArticleCellular & molecular biology letters2025

Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8.

Jun-Qi Yang, Chen Wang, Ramesh C Nayak, Manohar Kolla, Mingjun Cai, Mario Pujato, Yi Zheng, Q Richard Lu, Fukun Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Research Progress of Molecular HDrug design, development and therapy · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun-Qi YangDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Chen WangDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Ramesh C NayakDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Manohar KollaDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Mingjun CaiDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Mario PujatoLife Sciences Computational Services LLC, Huntingdon Valley, PA, 19006, USA.
Yi ZhengDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Q Richard LuDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. richard.lu@cchmc.org.ORCID http://orcid.org/0000-0001-6846-9014
Fukun GuoDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. fukun.guo@cchmc.org.ORCID http://orcid.org/0000-0002-8820-7633

Funding

Rational targeting of Cdc42 to benefit immunotherapyR01CA278756 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI Fukun Guo, YI ZHENG · 2024 to 2026
$1.8M
NCI NIH HHS R01CA234038-01A1NCI NIH HHS R01 CA278756NCI NIH HHS R01CA278756-01A1
6 · The paper itself

Abstract

backgroundChromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) defines a subtype of autism that is associated with immune disorders. It remains unknown whether CHD8 plays a cell-intrinsic role in immune cells such as regulatory T cells (Tregs) that maintain immune tolerance through suppressing CD4

methodsTreg-specific conditional CHD8-deficient mice were generated by crossing Chd8

resultsWe found that Treg-specific CHD8 deletion led to early, fatal inflammation owing to increased CD4

conclusionsOur findings suggest that CHD8 plays an important role in maintaining Treg fitness through genetic and epigenetic mechanisms to control autoimmunity, which may have important implications in immune changes in autism.

Indexed as

DNA-Binding ProteinsEpigenesis, GeneticT-Lymphocytes, RegulatoryAnimalsCD8-Positive T-LymphocytesChromatin Assembly and DisassemblyMiceMice, Inbred C57BLMice, TransgenicDNA-Binding ProteinsCHD8Chromatin remodelingGene expressionTregTreg plasticity

Identifiers

PMID40155813
PMCPMC11954365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.