Evidence map›Paper›PMID 40155794›Full record

Observational studyBMC emergency medicine2025

Comparison of Standardized Mortality Ratios in seven Dutch EDs based on presenting complaints.

Wouter Raven, Bart G J Candel, Nabila Wali, Menno I Gaakeer, Ewoud Ter Avest, Ozcan Sir, Heleen Lameijer, Roger A P A Hessels, Resi Reijnen, Christian H Nickel and 3 more

Abstract readObservational StudyMulticenter StudyComparative Study
In one paragraph

Observational study in BMC emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wouter RavenDepartment of Emergency Medicine, Leiden University Medical Centre, Albinusdreef 2, Leiden, RC, 2300, The Netherlands. w.raven@lumc.nl.
Bart G J CandelDepartment of Emergency Medicine, Leiden University Medical Centre, Albinusdreef 2, Leiden, RC, 2300, The Netherlands.
Nabila WaliDepartment of Emergency Medicine, Leiden University Medical Centre, Albinusdreef 2, Leiden, RC, 2300, The Netherlands.
Menno I GaakeerDepartment of Emergency Medicine, Adrz Hospital, 's-Gravenpolderseweg 114, Goes, RA, 4462, The Netherlands.
Ewoud Ter AvestDepartment of Emergency Medicine, University Medical Centre Groningen, Hanzeplein 1, Groningen, GZ, 9713, The Netherlands.
Ozcan SirDepartment of Emergency Medicine, Radboud University Medical Centre, Geert Grooteplein-Zuid, Postbus, Nijmegen, HB, 9101, 6500, The Netherlands.
Heleen LameijerDepartment of Emergency Medicine, Medical Centre Leeuwarden, Henri Dunantweg 2, Leeuwarden, AD, 8934, The Netherlands.
Roger A P A HesselsDepartment of Emergency Medicine, Elisabeth-TweeSteden Hospital, Doctor Deelenlaan 5, Tilburg, AD, 5042, The Netherlands.
Resi ReijnenDepartment of Emergency Medicine, Haaglanden Medical Centre, Lijnbaan 32, The Hague, VA, 2512, The Netherlands.
Christian H NickelDepartment of Emergency Medicine, University Hospital Basel, University of Basel, Petersgraben 4, Switzerland.
Evert de JongeDepartment of Intensive Care, Leiden University Medical Centre, Albinusdreef 2, Leiden, RC, 2300, The Netherlands.
Erik van ZwetDepartment of Medical Statistics, Leiden University Medical Centre, Albinusdreef 2, Leiden, RC, 2300, The Netherlands.
Bas de GrootDepartment of Emergency Medicine, Radboud University Medical Centre, Geert Grooteplein-Zuid, Postbus, Nijmegen, HB, 9101, 6500, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComparison of emergency departments (EDs) becomes more important, but differences are difficult to interpret because of the heterogeneity of the ED population regarding reason for ED presentation. The aim of this study was two-fold: First to compare patient characteristics (including diagnoses) across 7 EDs. Secondly, to compare Standardized Mortality Ratios (SMRs) across 7 EDs and in subgroups of ED patients categorized by presenting complaints (PCs).

methodsObservational multicenter study including all consecutive visits of 7 Dutch (two tertiary care centre and 5 teaching hospitals) EDs. Patient characteristics, including PCs as part of triage systems, and SMRs (observed divided by expected in-hospital mortality) per ED and for the most common PCs (PC-SMRs) were compared across EDs and presented as funnel plots. The expected mortality was calculated with a prediction model, which was developed using multivariable logistic regression in the overall population and for PCs separately. Demographics, disease severity, diagnoses, proxies for comorbidity and complexity, and PCs (overall population only) were incorporated as covariates.

resultsWe included 693,289 ED visits from January 1, 2017 to June 31, 2023, with a median age of 56 years, of which 47.9% were women and 1.9% died. Patient characteristics varied markedly among EDs. Expected mortality was similar in prediction models with or without diagnoses as covariate. SMRs differed across EDs, ranging from 0.80 to 1.44. All EDs had SMRs within the 95%-Confidence Intervals of the funnel plot apart from one ED, which had an higher than expected SMR. However, PC-SMRs showed more variation and more EDs had SMRs falling outside the funnel, either higher or lower than expected. The ranking of SMRs across EDs was PC-dependent and differences across EDs are present only for specific PC-SMRs, such as in "dyspnea" and "feeling unwell".

conclusionIn summary, patient characteristics and mortality varied largely across Dutch EDs, and expected mortality across EDs is well assessed in PC subgroups without adjustment for final diagnoses. Differences in SMRs across EDs are PC-dependent. Future studies should investigate reasons of the differences in PC-SMRs across EDs and whether PC-targeted quality improvement programs can improve outcomes.

Indexed as

Emergency Service, HospitalHospital MortalityAdultAgedFemaleHumansMaleMiddle AgedNetherlandsTriageEmergency departmentIn-hospital mortalityPresenting complaintsRisk stratificationStandardized mortality ratioSymptom-basedSymptom-oriented research

Identifiers

PMID40155794
PMCPMC11951612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.