Evidence map›Paper›PMID 40155747›Full record

ArticleJournal of human genetics2025

Significance of noninvasive prenatal testing using massively parallel sequencing in women with twin or vanishing twin pregnancies.

Eri Takeda, Nobuhiro Suzumori, Osamu Samura, Kiyonori Miura, Yoshimasa Kamei, Hideaki Sawai, Takahiro Yamada, Kiyotake Ichizuka, Reina Komatsu, Seiji Wada and 16 more

Abstract read
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In one paragraph

Article in Journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Eri TakedaDepartment of Obstetrics and Gynecology, Division of Clinical and Molecular Genetic, Nagoya City University, Graduate School of Medical Sciences, Nagoya, 467-8601, Japan. takedagc@med.nagoya-cu.ac.jp.ORCID http://orcid.org/0000-0002-5278-7074
Nobuhiro SuzumoriDepartment of Obstetrics and Gynecology, Division of Clinical and Molecular Genetic, Nagoya City University, Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
Osamu SamuraDepartment of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan.
Kiyonori MiuraDepartment of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yoshimasa KameiDepartment of Obstetrics and Gynecology, Saitama Medical University School of Medicine, Moroyama, Iruma, Saitama, Japan.
Hideaki SawaiDepartment of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Takahiro YamadaDivision of Clinical Genetics, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Kiyotake IchizukaDepartment of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa, Japan.
Reina KomatsuDepartment of Obstetrics and Gynecology, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Seiji WadaCenter of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Yukiko KatagiriDepartment of Obstetrics and Gynecology, Faculty of Medicine, Toho University, Tokyo, Japan.
Hiroko MorisakiDepartment of Medical Genetics, Sakakibara Heart Institute, Tokyo, Japan.
Setsuko NakayamaMaternal and Child Health Center, Aiiku Hospital, Tokyo, Japan.
Haruka HamanoueDepartment of Clinical Genetics, Yokohama City University Hospital, Yokohama, Kanagawa, Japan.
Jun MurotsukiDepartment of Maternal and Fetal Medicine, Tohoku University Graduate School of Medicine, Miyagi Children's Hospital, Sendai, Miyagi, Japan.
Kazuya MimuraDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Yuko MatsubaraDepartment of Obstetrics and Gynecology, Ehime University Graduate School of Medicine, Ehime, Japan.
Kazuhisa MaedaDepartment of Obstetrics and Gynecology, Shikoku Medical Center for Children and Adults, Zentsuji, Kagawa, Japan.
Akinori IdaDepartment of Obstetrics and Gynecology, Kobe Adventist Hospital, Hyogo, Japan.
Mika ItoDepartment of Obstetrics and Gynaecology, University of Toyama, Toyama, Japan.
Hiromi HayakawaDepartment of Obstetrics, Aichi Children's Health and Medical Center, Aichi, Japan.
Arisa FujiwaraDepartment of Obstetrics and Gynecology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Nahoko ShiratoDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Tatsuko IshiiDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Haruhiko SagoSanno Birth Center, Tokyo, Japan.
Akihiko SekizawaDepartment of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noninvasive prenatal testing diagnoses fetal aneuploidies in singleton pregnancies with trisomy 21, 18, or 13 accurately. However, clinical data on noninvasive prenatal testing in women with twin or vanishing twin pregnancies are limited. We report on the accuracy and prenatal and neonatal outcomes of noninvasive prenatal testing in twin and vanishing twin pregnancies. This retrospective study was conducted at 22 facilities belonging to the Noninvasive Prenatal Testing Consortium, part of a nationwide project in Japan, visited by women with twin or vanishing twin pregnancies between January 2015 and March 2022. This study investigated the accuracy and perinatal and neonatal outcomes of noninvasive prenatal testing using massively parallel sequencing in twin or vanishing twin pregnancies. Of 1013 women with twin pregnancies, 986 (97.3%) had negative; 13 (1.3%), positive; and 14 (1.4%), non-reportable noninvasive prenatal testing results. Of 225 women with vanishing twins, 203 (90.2%) had negative; 11 (4.9%), positive; and 11 (4.9%), non-reportable results. Among 1693 fetuses (77.3%) excluding 497 unknowns were available for follow-up, 1476 were from twin pregnancies, and 134 were from vanishing twin pregnancies, totaling 1610 babies has born. No false negatives were observed in the cases followed. These results indicate that noninvasive prenatal testing is useful for vanishing twin pregnancies and provide reassurance for pregnant women with twins and vanishing twins.

Indexed as

High-Throughput Nucleotide SequencingNoninvasive Prenatal TestingPregnancy, TwinPrenatal DiagnosisAdultAneuploidyDown SyndromeFemaleGenetic TestingHumansInfant, NewbornJapanPregnancyRetrospective Studies

Identifiers

PMID40155747

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.