Evidence map›Paper›PMID 40155701›Full record

Articlenpj antimicrobials and resistance2025

Integrating socioeconomic deprivation indices and electronic health record data to predict antimicrobial resistance.

Marlon I Diaz, Lauren N Cooper, John J Hanna, Alaina M Beauchamp, Tanvi A Ingle, Abdi D Wakene, Zachary Most, Trish Perl, Chaitanya Katterpalli, Tony Keller and 3 more

Abstract read
In one paragraph

Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. A One Health Perspective onMicroorganisms · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marlon I DiazCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Marlon.Diaz@ttuhsc.edu.
Lauren N CooperCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John J HannaCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alaina M BeauchampCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tanvi A IngleCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abdi D WakeneCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zachary MostCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Trish PerlCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chaitanya KatterpalliTexas Health Resources, Arlington, TX, USA.
Tony KellerTexas Health Resources, Arlington, TX, USA.
Clark WalkerTexas Health Resources, Arlington, TX, USA.
Christoph U LehmannCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Richard J MedfordCenter for Clinical Informatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3M
Measuring and Predicting Appropriate Antibiotic Use to Combat Resistant BacteriaR01AI178121 · NIAID · STANFORD UNIVERSITY · PI JONATHAN H. CHEN · 2023 to 2026
$3.1M
Centers for Disease Control and Prevention Foundation U01CK000590NCATS NIH HHS UL1 TR003163NCEZID CDC HHS U01 CK000590NIAID NIH HHS R01 AI178121NIH HHS 1R01AI178121
6 · The paper itself

Abstract

We developed machine learning models to predict the presence of AMR organisms in blood cultures obtained at the first patient encounter, offering a new and inspiring direction for antimicrobial resistance management. Three supervised machine learning classifiers were used: penalized logistic regression, random forest, and XGBoost, which were used to classify five AMR organisms: ESBL, CRE, AmpC, MRSA, and VRE. The random forest and XGBoost models performed best, with AUC-ROC values of 0.70 and 92.9% negative predictive value, respectively. The multi-class random forest model's AUC-ROC values ranged from 0.80-0.95. Our models highlight how the combination of ADI and SVI increased the predictive power. This approach could reduce costs and mitigate the global public health threat posed by antibiotic-resistant infections. Machine learning techniques can predict antimicrobial-resistant infections in suspected cultures using patient data from EHRs, enabling clinicians to make targeted prescribing decisions and mitigate resistance development.

Identifiers

PMID40155701
PMCPMC11953338

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.