Evidence map›Paper›PMID 40155633›Full record

ArticleNature communications2025

Controlling outer-sphere solvent reorganization energy to turn on or off the function of artificial metalloenzymes.

Divyansh Prakash, Suchitra Mitra, Simran Sony, Morgan Murphy, Babak Andi, Landon Ashley, Pallavi Prasad, Saumen Chakraborty

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Engineering an Artificial Metalloenzyme for Efficient Photo-Enzymatic COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Divyansh PrakashDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA.ORCID http://orcid.org/0000-0001-5025-3135
Suchitra MitraDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA.
Simran SonyDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA.
Morgan MurphyDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA.
Babak AndiCenter for BioMolecular Structure, National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, USA.ORCID http://orcid.org/0000-0002-7666-639X
Landon AshleyDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA.
Pallavi PrasadDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA.
Saumen ChakrabortyDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, USA. saumenc@olemiss.edu.ORCID http://orcid.org/0000-0002-9256-2769

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
Michigan Economic Development Corporation (MEDC) 085P1000817National Science Foundation (NSF) 1726244NIGMS NIH HHS P30 GM133893NIGMS NIH HHS P30 GM133894U.S. Department of Energy (DOE) DE-AC02-06CH11357U.S. Department of Energy (DOE) DE-AC02-76SF00515
6 · The paper itself

Abstract

Metalloenzymes play essential roles in biology. However, unraveling how outer-sphere interactions can be predictably controlled to influence their functions remains a significant challenge. Inspired by Cu enzymes, we demonstrate how variations in the primary, secondary, and outer coordination-sphere interactions of de novo designed artificial copper proteins (ArCuPs) within trimeric (3SCC) and tetrameric (4SCC) self-assemblies-featuring a trigonal Cu(His)

Indexed as

CopperMetalloproteinsSolventsCatalysisElectron TransportHydrogen BondingHydrogen PeroxideModels, MolecularOxidation-ReductionCopperHydrogen PeroxideMetalloproteinsSolvents

Identifiers

PMID40155633
PMCPMC11953277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.