Evidence map›Paper›PMID 40155531›Full record

ReviewDiscover oncology2025

Cytokine biomarkers for independent prediction of hepatocellular carcinoma prognosis.

Long-Bin Jeng, Fu-Ying Shih, Wen-Ling Chan, Chiao-Fang Teng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Long-Bin JengOrgan Transplantation Center, China Medical University Hospital, Taichung, 404, Taiwan.
Fu-Ying ShihPh.D. Program for Biotech Pharmaceutical Industry, China Medical University, Taichung, 404, Taiwan.
Wen-Ling ChanDepartment of Public Health, College of Public Health, China Medical University, Taichung, 404, Taiwan.
Chiao-Fang TengOrgan Transplantation Center, China Medical University Hospital, Taichung, 404, Taiwan. chiaofangteng@gmail.com.ORCID http://orcid.org/0000-0002-5218-0571

Funding

China Medical University, Taichung, Taiwan CMU113-ASIA-13
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Although various therapeutic modalities have been established for HCC, the overall outcomes of patients after treatment remain unsatisfactory, highlighting the need for valuable independent prognostic biomarkers. Cytokines are a large group of multifunctional secretory proteins and play critical roles in regulating development and progression of many cancer types, including HCC. Moreover, the expression levels of many cytokines in tumor/peritumor tissues and serum/plasma samples have been validated as important biomarkers for independently predicting the prognosis of HCC patients. This review provides a comprehensive summary of literature evidence for the independent prognostic significance of cytokine biomarkers in HCC patients receiving different therapies.

Indexed as

CytokineHepatocellular carcinomaIndependent prognostic biomarkerIndependent prognostic significance

Identifiers

PMID40155531
PMCPMC11953510

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.