Evidence map›Paper›PMID 40155514›Full record

ArticleClinical journal of gastroenterology2025

Villous atrophy in celiac disease: striking differences in endoscopic findings between the duodenal bulb and descending duodenum.

Kenji Yamazaki, Ryoji Kushima, Noritaka Ozawa, Shogo Shimizu, Masahito Shimizu

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In one paragraph

Article in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenji YamazakiDepartment of Gastroenterology, Gifu Prefectural General Medical Center, 4-6-1 Noishiki, Gifu, 500-8717, Japan. yamayama-gi@umin.ac.jp.ORCID http://orcid.org/0000-0001-8563-7622
Ryoji KushimaDepartment of Pathology, Shiga University of Medical Science, Seta Tsukinowa-Cho, Otsu, Shiga, 520-2192, Japan.
Noritaka OzawaDepartment of Gastroenterology, Gifu Prefectural General Medical Center, 4-6-1 Noishiki, Gifu, 500-8717, Japan.
Shogo ShimizuDepartment of Gastroenterology, Gifu Prefectural General Medical Center, 4-6-1 Noishiki, Gifu, 500-8717, Japan.
Masahito ShimizuDepartment of Gastroenterology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A woman in her 40 s was diagnosed with celiac disease after a decade-long history of abdominal pain and abnormal bowel movements. We compared villous atrophy in the duodenal bulb (DB) and descending duodenum (DD) using endoscopic and histopathological findings. Endoscopy revealed villous loss, a fine granular pattern, and groove-like depressions in the DD that were clearly visualized under narrow-band imaging (NBI) magnification. Histopathological examination revealed villous loss, crypt elongation, and hyperplasia. In contrast, endoscopy revealed a mosaic pattern in the DB, and NBI revealed circular or oval glandular openings surrounded by wide marginal crypt epithelium. Histopathology revealed gastric-type foveolar metaplasia (GFM) associated with the Brunner's glands. The DB and DD exhibited distinct endoscopic features, with GFM in the DB likely resulting from damage to the small intestinal mucosa. Since Brunner's glands are abundant in the DB, GFM may develop; thus, villous atrophy may be more difficult to appreciate endoscopically in the DB than with the clearer image in the DD. Recognizing regional differences in endoscopic appearance is crucial for the accurate diagnosis of celiac disease and other causes of duodenal villous atrophy.

Indexed as

Celiac DiseaseDuodenumIntestinal MucosaAdultAtrophyBrunner GlandsDuodenoscopyFemaleHumansNarrow Band ImagingBrunner’s glandsCeliac diseaseDuodenumGastric-type foveolar metaplasiaVillous atrophy

Identifiers

PMID40155514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.