ArticleNature communications2025
PD-L1
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In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bibliometric and visual analysis of research trends and hotspots in sepsis-related immunosuppression (2005-2025).Frontiers in pharmacology · 2026Pooled it
- Convergent immune dysregulation in sepsis and colorectal cancer highlights plasma cells and identifies shared candidate genes.Discover oncology · 2026Article
- Integrated pan-cancer analysis and experimental validation reveal that syndecan-1 drives glioblastoma pathogenesis and associates with immune infiltration.Discover oncology · 2026Article
- The Dual Role of Interleukin-10 in Sepsis: Research Progress and Therapeutic Prospects.Inflammation · 2026Review
- Integrating single-cell transcriptomics and epigenetics in a multi-omics MR framework identifies PARK7 as a causal gene in streptococcal septicemia.Epigenetics & chromatin · 2026Article
- Multimodal radiomics for precision management of colorectal cancer.Discover oncology · 2026Review
- Chronic Kidney Disease-Associated Defect in Humoral Immune Response Is Driven by Inflammation.Toxins · 2026Article
- Bench-to-Bedside Insights into the Challenges of Immunosuppression in Sepsis.Pathogens (Basel, Switzerland) · 2026Review
- Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1.The Journal of clinical investigation · 2026Article
- Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial dysfunction in sepsis-induced immunoparalysis: from immune-cell metabolic reprogramming to clinical biomarkers.Frontiers in immunology · 2026Review
- Intracellular ATP Levels in CD4Journal of inflammation research · 2026Article
- Parallel single-cell host immune profiling and pathogen genomic characterization inFrontiers in cellular and infection microbiology · 2026Observational
- Intracellular PD-L1: Functions, Regulation, and Therapeutic Implications.International journal of biological sciences · 2026Review
- CXCR5-engineered mesenchymal stromal cells home to spleen and mitigate post-sepsis syndrome by preventing secondary infection.Stem cell research & therapy · 2025Article
- Research advances on the role of programmed endothelial cell death in sepsis.Cell death discovery · 2025Review
- Mechanisms of immune suppression in sepsis/shock: one investigator's/lab group's experience (SLB 2024 legacy award presentation).Journal of leukocyte biology · 2025Article
- Sepsis-Induced Endothelial Barrier Dysfunction: Mechanisms, Pathology, and Therapeutic Advances.Research (Washington, D.C.) · 2025Review
- Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes.EXCLI journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Morgane GossezHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.
Clara VigneronCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Alexandra VandermoetenService Commun des Animaleries de Rockefeller (SCAR) - Université Claude Bernard lyon1, Structure Fédérative de Recherche (SFR) Santé Lyon Est, Lyon, France.
Margot LepageHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.ORCID http://orcid.org/0009-0005-2050-6572
Louise CourcolCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Remy CoudereauHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.
Helena PaidassaiCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID http://orcid.org/0000-0001-9915-4365
Laurent JalladesCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Jonathan LopezHospices Civils de Lyon, Biochemistry and Molecular Biology department, Lyon Est Faculty of Medicine, Université Claude Bernard Lyon 1, Université de Lyon, Lyon Sud University Hospital, Pierre-Bénite, France.
Khalil KandaraHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.
Marine OrtillonHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.
Marine MommertEA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux), Lyon, France.
Astrid FabriHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.
Estelle PeronnetEA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux), Lyon, France.
Clémence GrosjeanEA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux), Lyon, France.
Marielle BuissonCentre d'Investigation Clinique de Lyon (CIC 1407 Inserm), Hospices Civils de Lyon, Lyon, France.
Anne-Claire LukaszewiczEA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux), Lyon, France.
Thomas RimmeléEA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux), Lyon, France.
Laurent ArgaudHospices Civils de Lyon, Medical Intensive Care Department, Edouard Herriot Hospital, Lyon, France.ORCID http://orcid.org/0000-0002-4565-2454
Martin CourHospices Civils de Lyon, Medical Intensive Care Department, Edouard Herriot Hospital, Lyon, France.ORCID http://orcid.org/0000-0003-4909-9761
REALISM study group
RICO study group
Bénédicte F PyCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID http://orcid.org/0000-0001-6716-7807
Olivier ThaunatCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-3648-8963
Thierry DefranceCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm U1111, Université Claude Bernard-Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-6943-358X
Guillaume MonneretHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France.ORCID http://orcid.org/0000-0002-9961-5739
Fabienne VenetHospices Civils de Lyon, Immunology Laboratory, Lyon-Sud & Edouard Herriot University Hospitals, Lyon, France. fabienne.venet@chu-lyon.fr.ORCID http://orcid.org/0000-0003-0462-4235
Funding
Agence Nationale de la Recherche (French National Research Agency) ANR-20-CE92-0024-01
Abstract
Sepsis, a leading cause of death in intensive care units, is associated with immune alterations that increase the patients' risk of secondary infections and mortality, so better understandings of the pathophysiology of sepsis-induced immunosuppression is essential for the development of therapeutic strategies. In a murine model of sepsis that recapitulates immune alterations observed in patients, here we demonstrate that PD-L1
Indexed as
B7-H1 AntigenPlasma CellsSepsisT-LymphocytesAgedAnimalsDisease Models, AnimalFemaleHumansInterferon-gammaMaleMiceMice, Inbred C57BLMiddle AgedSpleenB7-H1 AntigenCD274 protein, humanCd274 protein, mouseInterferon-gamma
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.