Evidence map›Paper›PMID 40155358›Full record

Trial reportAIDS care2025

People who inject drugs and men who have sex with men living with HIV in India experience low probability of viral rebound and high levels of persistent viremia during the first 12 months of antiretroviral therapy.

Talia A Loeb, Sunil S Solomon, Mihili P Gunaratne, A K Srikrishnan, C K Vasudevan, Rifa T Khan, Santhanam Anand, Boobalan Jayaseelan, Muniratnam Suresh Kumar, David D Celentano and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Talia A LoebDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sunil S SolomonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mihili P GunaratneDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
A K SrikrishnanYR Gaitonde Centre for AIDS Research and Education, Chennai, India.
C K VasudevanYR Gaitonde Centre for AIDS Research and Education, Chennai, India.
Rifa T KhanYR Gaitonde Centre for AIDS Research and Education, Chennai, India.
Santhanam AnandYR Gaitonde Centre for AIDS Research and Education, Chennai, India.
Boobalan JayaseelanYR Gaitonde Centre for AIDS Research and Education, Chennai, India.
Muniratnam Suresh KumarYR Gaitonde Centre for AIDS Research and Education, Chennai, India.
David D CelentanoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Gregory M LucasDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shruti H MehtaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Allison M McFallDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Strategies to improve the HIV care continuum among key populations in IndiaR01DA041034 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M, MEHTA, SHRUTI H · 2015 to 2021
$6.7M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
Treatment outcomes and comorbidity in HIV-infected IDUK24DA035684 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2014 to 2024
$1.5M
NIAID NIH HHS P30 AI094189NIAID NIH HHS T32 AI102623NIDA NIH HHS K24 DA035684NIDA NIH HHS R01 DA041034
6 · The paper itself

Abstract

People who inject drugs (PWID) and men who have sex with men (MSM) in India are disproportionately affected by HIV and experience challenges achieving sustained viral suppression. We evaluated probabilities of suppression over time and characteristics associated with persistent viremia and viral rebound among MSM and PWID living with HIV (PLHIV) using 12 months of data collected between 2017-2019 from a cluster-randomized trial across 16 cities in India. To assessprobabilities of suppression, we fit logistic transition models with generalized estimating equations. To assess correlates of persistent viremia and viral rebound, we fit multivariable multilevel logistic regression models. Of 750 PWID, 88% were male and 14% completed high school. Of 850 MSM, 29% completed high school and 54% were married. 46% of PWID and 67% of MSM maintained viral suppression once achieved. Probabilities of viral rebound decreased over time. The probability of newly achieving suppression decreased, from 33%-12% after six months among PWID and 60%-13% among MSM. Among PWID, correlates of persistent viremia included lower education, employment, homelessness, and active injection. Among MSM, hazardous alcohol use was associated with viremia and viral rebound. Treatment engagement and support efforts need to be intensified to encourage PLHIV to achieve life-long suppression.

Indexed as

Anti-HIV AgentsHIV InfectionsHomosexuality, MaleSubstance Abuse, IntravenousViremiaAdultHumansIndiaMaleMiddle AgedViral LoadAnti-HIV AgentsHIVHIV viral suppressionIndiamen who have sex with menpeople who inject drugsSDG10: reduced inequalitiesSDG3: good health and well-beingviral rebound

Identifiers

PMID40155358
PMCPMC12400641

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.