Evidence map›Paper›PMID 40155326›Full record

ArticleFuture oncology (London, England)2025

S2303: phase II/III trial of paclitaxel + ramucirumab ± nivolumab in gastric and esophageal adenocarcinoma (PARAMUNE).

Anwaar Saeed, Sarah Colby, Paul Eliezer Oberstein, Dan G Duda, Robin Park, Rajiv Agarwal, Colmar Figueroa-Moseley, Riha Vaidya, Joseph M Unger, Katherine A Guthrie and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06203600 (Randomized Phase II/III Trial of 2nd Line Nivolumab + Paclitaxel + Ramucirumab Versus Paclitaxel + Ramucirumab in Patients With PD-L1 CPS >/= 1 Advanced Gastric and Esophageal Adenocarcinoma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06203600 phase2 / phase3recruitingnot on this map

Randomized Phase II/III Trial of 2nd Line Nivolumab + Paclitaxel + Ramucirumab Versus Paclitaxel + Ramucirumab in Patients With PD-L1 CPS >/= 1 Advanced Gastric and Esophageal Adenocarcinoma (PARAMUNE)

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2024 to 2027Enrolled224ConditionsAdvanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma, Clinical Stage II Esophageal Adenocarcinoma AJCC v8ArmsBiospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Nivolumab, Paclitaxel
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anwaar SaeedDepartment of Medicine, Division of Hematology & Oncology, UPMC Hillman Cancer Center, Pittsburgh, PL, USA.
Sarah ColbySWOG Statistical and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Paul Eliezer ObersteinDepartment of Medicine, Division of Hematology & Oncology, NYU Langone Cancer Center, New York, NY, USA.
Dan G DudaDepartment of Radiation Oncology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Robin ParkDepartment of Hematology/Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Rajiv AgarwalDepartment of Medicine, Division of Hematology & Oncologyy, Vanderbilt Ingram Cancer Center, Nashville, TN, USA.
Colmar Figueroa-MoseleyDepartment of Population Health, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA.
Riha VaidyaSWOG Statistical and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Joseph M UngerSWOG Statistical and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Katherine A GuthrieSWOG Statistical and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Flavio G RochaDepartment of Surgery, Division of Surgical Oncology, Oregon Health & Science University, Portland, OR, USA.
Maheswari SenthilDepartment of Surgery, Division of Surgical Oncology, University of California Irvine Cancer Center, Irvine, CA, USA.
Rachael A SafyanDepartment of Medicine, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
Zev A WainbergDepartment of Medicine, Division of Hematology & Oncology, UCLA Johnson Comprehensive Cancer Center, Santa Monica, CA, USA.
Syma IqbalDepartment of Medicine, Division of Hematology & Oncology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
E Gabriela ChioreanDepartment of Medicine, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
Philip A PhilipDepartment of Medicine, Division of Hematology & Oncology, Wayne State University, Detroit, MI, USA.

Funding

SWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1M
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
SWOG Statistics & Data Management Center complex - extension supplement for GY06U10CA180819 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MEGAN OTHUS · 2014 to 2026
$115.2M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
NCI NIH HHS P30 CA016042NCI NIH HHS U10 CA180819NCI NIH HHS U10 CA180888NCI NIH HHS UG1 CA189974
6 · The paper itself

Abstract

trial registration numberNCT06203600.

Indexed as

AdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsEsophageal NeoplasmsStomach NeoplasmsAgedAntibodies, Monoclonal, HumanizedClinical Trials, Phase II as TopicClinical Trials, Phase III as TopicFemaleHumansMaleMiddle AgedNivolumabPaclitaxelRamucirumabAntibodies, Monoclonal, HumanizedNivolumabPaclitaxelRamucirumabanti-programmed death-1combined positive scoregastric, gastroesophageal junction, or esophageal cancerImmunotherapypaclitaxelramucirumabvascular endothelial growth factor

Identifiers

PMID40155326
PMCPMC12051544

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.