Evidence map›Paper›PMID 40154905›Full record

ArticleRespiratory physiology & neurobiology

Chemogenetic activation of the diaphragm after spinal cord injury in rats.

Ethan S Benevides, Sabhya Rana, David D Fuller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ethan S BenevidesDepartment of Physical Therapy, University of Florida, Gainesville, FL 32601, United States; Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32601, United States.
Sabhya RanaDepartment of Physical Therapy, University of Florida, Gainesville, FL 32601, United States; Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32601, United States; McKnight Brain Institute, University of Florida, Gainesville, FL 32601, United States.
David D FullerDepartment of Physical Therapy, University of Florida, Gainesville, FL 32601, United States; Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL 32601, United States; McKnight Brain Institute, University of Florida, Gainesville, FL 32601, United States. Electronic address: dfuller@phhp.ufl.edu.

Funding

Control of Breathing & Glycogen Storage DiseaseR01HD052682 · NICHD · UNIVERSITY OF FLORIDA · PI BYRNE, BARRY J, FULLER, DAVID D · 2007 to 2024
$6.4M
Training Program for Applied Research and Development in Genomic MedicineT32HG008958 · NHGRI · UNIVERSITY OF FLORIDA · PI Larisa Humma Cavallari, Stephen E. Kimmel · 2018 to 2026
$3.8M
Hyperbaric oxygen therapy mitigates respiratoryneuromuscular pathology after spinal cord injuryR01HL153140 · NHLBI · UNIVERSITY OF FLORIDA · PI FULLER, DAVID D, WENDLER, CHRISTOPHER CHARLES · 2020 to 2023
$1.5M
NHGRI NIH HHS T32 HG008958NHLBI NIH HHS R01 HL153140NICHD NIH HHS R01 HD052682
6 · The paper itself

Abstract

We tested the hypothesis that activation of DREADDs in the mid-cervical spinal cord could restore diaphragm activation during spontaneous breathing after cervical spinal cord injury (SCI). Adult Sprague Dawley rats (n = 7) received bilateral mid-cervical ventral horn injections of an AAV construct encoding an excitatory DREADD (AAV9-hSyn-HA-hM3D(Gq)-mCherry; titer: 2.44 × 10

Indexed as

DiaphragmSpinal Cord InjuriesAnimalsCervical CordChemogeneticsDisease Models, AnimalElectromyographyFemaleMaleRatsRats, Sprague-DawleyAdeno-associated virusChemogeneticsDiaphragm EMGDREADDPhrenicRespiratory neural controlRespiratory rehabilitationSpinal cord injury

Identifiers

PMID40154905
PMCPMC13499367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.